ReviewFrontiers in physiology2021
Hypoxic Hypoxia and Brain Function in Military Aviation: Basic Physiology and Applied Perspectives.
Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06446427 (The Effect of Acute High Altitude Exposure on Rescuer Performance and Patient Care), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Acute High Altitude Exposure on Rescuer Performance and Patient Care
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Recovery from acute hypoxia: A systematic review of cognitive and physiological responses during the 'hypoxia hangover'.PloS one · 2023Pooled it
- An unblinded training exposure to hypoxia enhances subsequent hypoxia awareness.Diving and hyperbaric medicine · 2025Trial
- Positive pressure ventilation improves oxygen saturation at altitude during recreational aviation: A pilot study.Physiological reports · 2025Trial
- Ketone monoester attenuates declines in cognitive performance and oxygen saturation during acute severe hypoxic exposure under resting conditions.Experimental physiology · 2024Trial
- Ketone monoester attenuates oxygen desaturation during weighted ruck exercise under acute hypoxic exposure but does not impact cognitive performance.Experimental physiology · 2024Trial
- Effect of oxygen supplementation on cognitive performance among HEMS providers after acute exposure to altitude: the HEMS II randomized clinical trial.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Trial
- Trial
- The effects of normobaric and hypobaric hypoxia on cognitive performance and physiological responses: A crossover study.PloS one · 2022Trial
- Neural and behavioral correlates of consciousness: the welfare consequences of fatal hypobaric and hypercapnic hypoxia in laboratory mice.Lab animal · 2026Article
- Hazards associated with superconducting magnet quench events: system requirements, application and consequences.Magma (New York, N.Y.) · 2026Review
- A comparison of normobaric and hypobaric hypoxia effects on cerebrovascular response pre and post maximal exercise.Experimental physiology · 2026Article
- High-Altitude Pilot Physiological Monitoring Dataset: Respiratory Performance and SpO₂ Analysis.Scientific data · 2026Article
- Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway.Scientific reports · 2026Article
- Effects of acute hypoxic exposure on multiple-object tracking ability of flight trainees.Frontiers in psychology · 2026Article
- Development and validation of an AI-driven blood glucose prediction system for pilots based on continuous glucose monitoring.Frontiers in physiology · 2026Article
- Aerospace stressors and brain health in military aviators: a glymphatic-neurovascular framework.Frontiers in physiology · 2026Review
- Human limits in next-generation fighter aviation: psychophysiological stressors, readiness, health, performance, and countermeasures.Frontiers in physiology · 2026Review
- From G tolerance to physiological state monitoring: mechanisms and adaptive protection.Frontiers in physiology · 2026Review
- Mild hypoxia adversely impacts human vestibular function.Scientific reports · 2025Article
- A Single Bout of Intermittent Hypoxia Increases Cerebral Blood Flow and Supports an Executive Function Benefit.Psychophysiology · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute hypobaric hypoxia (HH) is a major physiological threat during high-altitude flight and operations. In military aviation, although hypoxia-related fatalities are rare, incidences are common and are likely underreported. Hypoxia is a reduction in oxygen availability, which can impair brain function and performance of operational and safety-critical tasks. HH occurs at high altitude, due to the reduction in atmospheric oxygen pressure. This physiological state is also partially simulated in normobaric environments for training and research, by reducing the fraction of inspired oxygen to achieve comparable tissue oxygen saturation [normobaric hypoxia (NH)]. Hypoxia can occur in susceptible individuals below 10,000 ft (3,048 m) in unpressurised aircrafts and at higher altitudes in pressurised environments when life support systems malfunction or due to improper equipment use. Between 10,000 ft and 15,000 ft (4,572 m), brain function is mildly impaired and hypoxic symptoms are common, although both are often difficult to accurately quantify, which may partly be due to the effects of hypocapnia. Above 15,000 ft, brain function exponentially deteriorates with increasing altitude until loss of consciousness. The period of effective and safe performance of operational tasks following exposure to hypoxia is termed the time-of-useful-consciousness (TUC). Recovery of brain function following hypoxia may also lag beyond arterial reoxygenation and could be exacerbated by repeated hypoxic exposures or hyperoxic recovery. This review provides an overview of the basic physiology and implications of hypoxia for military aviation and discusses the utility of hypoxia recognition training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.