ArticleFrontiers in physiology2021
Alteration of Autonomic Nervous System Is Associated With Severity and Outcomes in Patients With COVID-19.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- The developments and emerging trends of Autonomic Nervous System Research in Arrhythmia: a bibliometric study from 2004 to 2024.Frontiers in neuroscience · 2025Pooled it
- Wearable Devices to Diagnose and Monitor the Progression of COVID-19 Through Heart Rate Variability Measurement: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2023Pooled it
- The Impact of SARS-CoV-2 Infection on Heart Rate Variability: A Systematic Review of Observational Studies with Control Groups.International journal of environmental research and public health · 2023Pooled it
- Non-Invasive Multimodal Neuromonitoring in Non-Critically Ill Hospitalized Adult Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2022Pooled it
- Impact of COVID‑19 infection on subsequent prescriptions of autonomic dysfunction pharmacotherapy: a nationwide propensity‑score‑matched Cohort study in Japan.Annals of medicine · 2026Article
- Significance and Usefulness of High-Resolution 24-h Electrocardiographic Parameters in Patients With Coronavirus Disease 2019 After Admission: A Prospective Cohort Study.Journal of arrhythmia · 2026Article
- Classification of Individuals With COVID-19 and Post-COVID-19 Condition and Healthy Controls Using Heart Rate Variability: Machine Learning Study With a Near-Real-Time Monitoring Component.Journal of medical Internet research · 2025Article
- Predictors of fatigue progression in long COVID among young people.Brain, behavior, & immunity - health · 2025Article
- Article
- Autonomic Function and Baroreflex Control in COVID-19 Patients Admitted to the Intensive Care Unit.Journal of clinical medicine · 2024Article
- Review
- Cardiovascular Autonomic Nervous System in a Patient With Hereditary Angioedema Affected by COVID-19.Cureus · 2024Article
- Cardiac autonomic function in post-COVID-19 patients and its impact on haemodynamics during neurosurgery - A prospective observational study.Indian journal of anaesthesia · 2024Article
- Asymptomatic Autonomic Dysregulation after Recovery from Mild COVID-19 Infection Revealed by Analysis of Heart Rate Variability Responses to Task Load.Healthcare (Basel, Switzerland) · 2023Article
- The Relationship between Paresthesia and the Presence of Cardiac Dysautonomia in Patients with Post-COVID-19 Syndrome: A Preliminary Observational Study.Brain sciences · 2023Article
- COVID-19: Insights into long-term manifestations and lockdown impacts.Journal of sport and health science · 2023Review
- Study of sympathetic skin response in patients with COVID-19 infection.Acta neurologica Belgica · 2023Article
- Acupoint stimulation for long COVID: A promising intervention:.World journal of acupuncture-moxibustion · 2023Review
- Imbalance of Peripheral Temperature, Sympathovagal, and Cytokine Profile in Long COVID.Biology · 2023Article
- Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies.Healthcare (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies suggest that coronavirus disease 2019 (COVID-19) is a systemic infection involving multiple systems, and may cause autonomic dysfunction.
objectiveTo assess autonomic function and relate the findings to the severity and outcomes in COVID-19 patients.
methodsWe included consecutive patients with COVID-19 admitted to the 21st COVID-19 Department of the east campus of Renmin Hospital of Wuhan University from February 6 to March 7, 2020. Clinical data were collected. Heart rate variability (HRV), N-terminal pro-B-type natriuretic peptide (NT-proBNP), D-dimer, and lymphocytes and subsets counts were analysed at two time points: nucleic-acid test positive and negative. Psychological symptoms were assessed after discharge.
resultsAll patients were divided into a mild group (13) and a severe group (21). The latter was further divided into two categories according to the trend of HRV. Severe patients had a significantly lower standard deviation of the RR intervals (SDNN) (
conclusionHRV was associated with the severity of COVID-19. The changing trend of HRV was related to the prognosis, indicating that HRV measurements can be used as a non-invasive predictor for clinical outcome.
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