Evidence map›Paper›PMID 34093166›Full record

ArticleFrontiers in aging neuroscience2021

White Matter Integrity Involvement in the Preclinical Stage of Familial Creutzfeldt-Jakob Disease: A Diffusion Tensor Imaging Study.

Donglai Jing, Yaojing Chen, Kexin Xie, Yue Cui, Chunlei Cui, Li Liu, Hui Lu, Jing Ye, Ran Gao, Lin Wang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Prion Mutations in Republic of Republic of Korea, China, and Japan.International journal of molecular sciences · 2022
    Review
  2. A longitudinalJournal of neurology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Donglai JingDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yaojing ChenState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Kexin XieDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yue CuiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chunlei CuiDepartment of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Li LiuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Hui LuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jing YeDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Ran GaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Lin WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhigang LiangDepartment of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhanjun ZhangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Liyong WuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNBeijing Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of the study was to explore patterns of white matter (WM) alteration in preclinical stage familial Creutzfeldt-Jakob disease (fCJD) using diffusion tensor imaging (DTI).

methodsSeven asymptomatic carriers of the

resultsNeither carriers nor non-carriers developed any neurological symptoms during 2 years of follow-up. Baseline analysis showed no differences between the carrier and non-carrier groups in MD and FA. Follow-up analysis showed significantly increased MD in multiple WM tracts, among which increased MD in the bilateral superior longitudinal fasciculus, bilateral anterior thalamic radiation, bilateral cingulate gyrus, and left uncinate fasciculus overlapped the patterns observed in patients with symptomatic CJD.

conclusionChanges in integrity within multiple WM tracts can be detected during the preclinical stage of fCJD.

Indexed as

Creutzfeldt–Jakob diseasediffusion tensor imagingpreclinical stagetract-based spatial statisticswhite matter

Identifiers

PMID34093166
PMCPMC8171061
OpenAlexW3160798467

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.