Evidence map›Paper›PMID 34093120›Full record

ReviewFrontiers in neuroscience2021

Growth Factors as Axon Guidance Molecules: Lessons From

Massimo M Onesto, Caitlin A Short, Sarah K Rempel, Timothy S Catlett, Timothy M Gomez

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. A gentle palette of plasma membrane dyes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Netrin-1 as A neural guidance protein in development and reinnervation of the larynx.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The regulatory landscape of neurite development inFrontiers in molecular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Massimo M OnestoNeuroscience Training Program and Cell and Molecular Biology Program, Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States.
Caitlin A ShortNeuroscience Training Program and Cell and Molecular Biology Program, Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States.
Sarah K RempelNeuroscience Training Program and Cell and Molecular Biology Program, Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States.
Timothy S CatlettNeuroscience Training Program and Cell and Molecular Biology Program, Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States.
Timothy M GomezNeuroscience Training Program and Cell and Molecular Biology Program, Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States.
University of Wisconsin–Madison · US

Funding

Mechanisms of mTOR-independent axon growth and guidance defects in TSC2 mutant human neuronsR01NS113314 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GOMEZ, TIMOTHY M · 2020 to 2024
$1.8M
Molecular mechanisms of growth cone invasionR01NS099405 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GOMEZ, TIMOTHY M · 2016 to 2019
$1.4M
Modeling Neural Development Using Human iPSCs from TSC PatientsR21NS088477 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GOMEZ, TIMOTHY M · 2014 to 2015
$414k
Molecular mechanisms of abnormal dendritic spine development and function in human neurons with TSC2 disease mutationsR21NS125419 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GOMEZ, TIMOTHY M · 2021 to 2021
$408k
NINDS NIH HHS R01 NS099405NINDS NIH HHS R01 NS113314NINDS NIH HHS R21 NS088477NINDS NIH HHS R21 NS125419
6 · The paper itself

Abstract

Growth cones at the tips of extending axons navigate through developing organisms by probing extracellular cues, which guide them through intermediate steps and onto final synaptic target sites. Widespread focus on a few guidance cue families has historically overshadowed potentially crucial roles of less well-studied growth factors in axon guidance. In fact, recent evidence suggests that a variety of growth factors have the ability to guide axons, affecting the targeting and morphogenesis of growth cones

Indexed as

cytoskeletondendritedevelopmentgrowth conespine

Identifiers

PMID34093120
PMCPMC8175860
OpenAlexW3163573606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.