Evidence map›Paper›PMID 34093113›Full record

ArticleFrontiers in neuroscience2021

Early-Stage Repetitive Transcranial Magnetic Stimulation Altered Posterior-Anterior Cerebrum Effective Connectivity in Methylazoxymethanol Acetate Rats.

Huiling Guo, Yao Xiao, Dandan Sun, Jingyu Yang, Jie Wang, Huaning Wang, Chunyu Pan, Chao Li, Pengfei Zhao, Yanbo Zhang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Huiling GuoDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yao XiaoEarly Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Dandan SunDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
Jingyu YangDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
Jie WangKey Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China.
Huaning WangDepartment of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Chunyu PanEarly Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Chao LiDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Pengfei ZhaoDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yanbo ZhangDepartment of Psychiatry, Faculty of Medicine and Dentistry, The Neuroscience and Mental Health Institute (NMHI), University of Alberta, Alberta, AB, Canada.
Jinfeng WuKey Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China.
Xizhe ZhangSchool of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.
Fei WangDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
China Medical University · CNNanjing Brain Hospital · CNWuhan National Laboratory for Optoelectronics · CNNanjing Medical University · CNNortheastern University · CNUniversity of Alberta · CAXijing Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the current resting-state functional magnetic resonance imaging (fMRI) study was to investigate the potential mechanism of schizophrenia through the posterior-anterior cerebrum imbalance in methylazoxymethanol acetate (MAM) rats and to evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as an early-stage intervention. The rats were divided into four groups: the MAM-sham group, vehicle-sham group, MAM-rTMS group, and vehicle-rTMS group. The rTMS treatment was targeted in the visual cortex (VC) in adolescent rats. Granger Causality Analysis (GCA) was used to evaluate the effective connectivity between regions of interest. Results demonstrated a critical right VC-nucleus accumbens (Acb)-orbitofrontal cortex (OFC) pathway in MAM rats; significant differences of effective connectivity (EC) were found between MAM-sham and vehicle-sham groups (from Acb shell to OFC:

Indexed as

functional magnetic resonance imagingGranger Causality Analysismethylazoxymethanol acetatenucleus accumbensrepetitive transcranial magnetic stimulationschizophreniavisual cortex

Identifiers

PMID34093113
PMCPMC8176023
OpenAlexW3164033675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.