Evidence map›Paper›PMID 34092978›Full record

ArticleWorld journal of gastroenterology2021

Understanding celiac disease monitoring patterns and outcomes after diagnosis: A multinational, retrospective chart review study.

Knut Ea Lundin, Ciaran P Kelly, David S Sanders, Kristina Chen, Sheena Kayaniyil, Sisi Wang, Rajvi J Wani, Caitlin Barrett, Shakira Yoosuf, Ellen S Pettersen and 2 more

Abstract read
In one paragraph

Article in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Knut Ea LundinK.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo 0450, Norway.
Ciaran P KellyCeliac Center Beth Israel Deaconess Medical Center, Celiac Research Program Harvard Medical School, Boston, MA 02115, United States.
David S SandersRoyal Hallamshire Hospital, University of Sheffield, Sheffield S10 2TN, United Kingdom.
Kristina ChenTakeda Pharmaceuticals International Co., Cambridge, MA 02139, United States.
Sheena KayaniyilReal World Evidence Strategy and Analytics, ICON plc., Toronto, ON L7N 3G2, Canada.
Sisi WangReal World Evidence Strategy and Analytics, ICON plc., Vancouver, BC V6B 1P1, Canada.
Rajvi J WaniReal World Evidence Strategy and Analytics, ICON plc., Toronto, ON L7N 3G2, Canada.
Caitlin BarrettCeliac Center Beth Israel Deaconess Medical Center, Celiac Research Program Harvard Medical School, Boston, MA 02115, United States.
Shakira YoosufCeliac Center Beth Israel Deaconess Medical Center, Celiac Research Program Harvard Medical School, Boston, MA 02115, United States.
Ellen S PettersenDepartment of Gastroenterology, Oslo University Hospital Rikshospitalet, Oslo 0372, Norway.
Robert SambrookReal World Evidence Strategy and Analytics, ICON plc., Vancouver, BC V6B 1P1, Canada.
Daniel A LefflerTakeda Pharmaceuticals International Co., Cambridge, MA 02139, United States. daniel.leffler@takeda.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong-term outcomes and monitoring patterns in real-world practice are largely unknown among patients with celiac disease.

aimTo understand patterns of follow-up and management of patients with celiac disease, and to characterize symptoms and villous atrophy after diagnosis.

methodsA retrospective chart review study was performed using medical chart data of patients diagnosed with celiac disease. Three gastroenterology referral centers, with substantial expertise in celiac disease, participated in the United Kingdom, United States, and Norway. Demographic and clinical data were collected from medical charts. Descriptive analyses were conducted on patients with biopsy-confirmed celiac disease, diagnosed between 2008 and 2012, with at least one follow-up visit before December 31, 2017. Patient demographic and clinical characteristics, biopsy/serology tests and results, symptoms, and comorbidities were captured at diagnosis and for each clinic visit occurring within the study period (

resultsA total of 300 patients were included in this study [72% female; mean age at diagnosis: 38.9 years, standard deviation (SD) 17.2]. Patients were followed-up for a mean of 29.9 mo (SD 22.1) and there were, on average, three follow-up visits

conclusionThis real-world study demonstrates variable follow-up of patients with celiac disease despite most patients continuing to have abnormal histology and symptoms after diagnosis.

Indexed as

Celiac DiseaseBiopsyFemaleHumansMaleNorwayRetrospective StudiesUnited KingdomUnited StatesCeliac diseaseEndoscopyGeneral practiceOutcomes researchReal-worldVillous atrophy

Identifiers

PMID34092978
PMCPMC8160626

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.