ArticleJMIR formative research2021
Artificial Intelligence-Based Chatbot for Anxiety and Depression in University Students: Pilot Randomized Controlled Trial.
Article in JMIR formative research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 13 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- Artificial intelligence and academic anxiety? a meta-analysis.BMC psychology · 2026Pooled it
- Efficacy, User Engagement, and Acceptability of Cognitive Behavioral Therapy-Oriented Psychological Chatbots for Adults With Depressive and/or Anxiety Symptoms: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- The Efficacy of Rule-Based Versus Large Language Model-Based Chatbots in Alleviating Symptoms of Depression and Anxiety: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- The Effectiveness of AI Chatbots in Alleviating Mental Distress and Promoting Health Behaviors Among Adolescents and Young Adults: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Effectiveness of AI-Driven Conversational Agents in Improving Mental Health Among Young People: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Artificial intelligence in mental health care: a systematic review of diagnosis, monitoring, and intervention applications.Psychological medicine · 2025Pooled it
- Artificial intelligence as a predictive tool for mental health status: Insights from a systematic review and meta-analysis.PloS one · 2025Pooled it
- Exploring the Role of Mobile Apps for Insomnia in Depression: Systematic Review.Journal of medical Internet research · 2024Pooled it
- Self-Administered Interventions Based on Natural Language Processing Models for Reducing Depressive and Anxiety Symptoms: Systematic Review and Meta-Analysis.JMIR mental health · 2024Pooled it
- Attrition in Conversational Agent-Delivered Mental Health Interventions: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2024Pooled it
- Concordance of randomised controlled trials for artificial intelligence interventions with the CONSORT-AI reporting guidelines.Nature communications · 2024Pooled it
- Examining the role of AI technology in online mental healthcare: opportunities, challenges, and implications, a mixed-methods review.Frontiers in psychiatry · 2024Pooled it
- Conversational Agent Interventions for Mental Health Problems: Systematic Review and Meta-analysis of Randomized Controlled Trials.Journal of medical Internet research · 2023Pooled it
- Comparison of an AI Chatbot With a Nurse Hotline in Reducing Anxiety and Depression Levels in the General Population: Pilot Randomized Controlled Trial.JMIR human factors · 2025Trial
- Mental Health Chatbot for Young Adults With Depressive Symptoms During the COVID-19 Pandemic: Single-Blind, Three-Arm Randomized Controlled Trial.Journal of medical Internet research · 2022Trial
- Breaking Barriers in Student Mental Health Care With AI-Enhanced Group Cognitive Behavioral Therapy: Pilot Feasibility Study.JMIR formative research · 2026Article
- The effectiveness of CBT-based NLP-enabled AI conversational agents for mental health intervention: a systematic review and meta-analysis.NPJ digital medicine · 2026Article
- Effectiveness of AI and rule-based conversational agents for depression, anxiety and stress: A meta-analysis.NPJ digital medicine · 2026Article
- Current Landscape of Mental Health Conversational Agents From a Trauma-Informed Care Lens: Scoping Review.JMIR mental health · 2026Article
- Neuropsychological Mechanisms Associated with the Effectiveness of AI-Delivered Health Promotion Programs: A Comprehensive Meta-Analysis.Brain sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArtificial intelligence-based chatbots are emerging as instruments of psychological intervention; however, no relevant studies have been reported in Latin America.
objectiveThe objective of the present study was to evaluate the viability, acceptability, and potential impact of using Tess, a chatbot, for examining symptoms of depression and anxiety in university students.
methodsThis was a pilot randomized controlled trial. The experimental condition used Tess for 8 weeks, and the control condition was assigned to a psychoeducation book on depression. Comparisons were conducted using Mann-Whitney U and Wilcoxon tests for depressive symptoms, and independent and paired sample t tests to analyze anxiety symptoms.
resultsThe initial sample consisted of 181 Argentinian college students (158, 87.2% female) aged 18 to 33. Data at week 8 were provided by 39 out of the 99 (39%) participants in the experimental condition and 34 out of the 82 (41%) in the control group. On an average, 472 (SD 249.52) messages were exchanged, with 116 (SD 73.87) of the messages sent from the users in response to Tess. A higher number of messages exchanged with Tess was associated with positive feedback (F
conclusionsThe students spent a considerable amount of time exchanging messages with Tess and positive feedback was associated with a higher number of messages exchanged. The initial results show promising evidence for the usability and acceptability of Tess in the Argentinian population. Research on chatbots is still in its initial stages and further research is needed.
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