Evidence map›Paper›PMID 34092204›Full record

ReviewJournal of toxicology and environmental health. Part B, Critical reviews2021

Improving the predictive value of bioaccessibility assays and their use to provide mechanistic insights into bioavailability for toxic metals/metalloids - A research prospectus.

Jennifer L Griggs, David J Thomas, Rebecca Fry, Karen D Bradham

Abstract readReview
In one paragraph

Review in Journal of toxicology and environmental health. Part B, Critical reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Bioaccessibility of metal (loid)s from fine particulate matter (PMEnvironmental science and pollution research international · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Potassium jarosite seeding of soils decreases lead and arsenic bioaccessibility: A path toward concomitant remediation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer L GriggsDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-9587-5621
David J ThomasChemical Characterization and Exposure Division, Center for Computational Toxicology & Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Rebecca FryDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-0899-9018
Karen D BradhamWatershed and Ecosystem Characterization Division, Center for Environmental Measurement and Modelling, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
NIEHS NIH HHS P30 ES010126NIEHS NIH HHS T32 ES007018
6 · The paper itself

Abstract

Widespread contamination of soil, dust, and food with toxic metal(loid)s pose a significant public health concern. Only a portion of orally ingested metal(loid) contaminants are bioavailable, which is defined as the fraction of ingested metal(loid)s absorbed across the gastrointestinal barrier and into systemic circulation. Bioaccessibility tools are a class of

Indexed as

AnimalsBiological AvailabilityEnvironmental ExposureEnvironmental MonitoringEnvironmental PollutionFood ContaminationHumansMetalloidsMetalsPublic HealthRisk AssessmentSoil PollutantsMetalloidsMetalsSoil PollutantsbioaccessibilityexposureIngestionmetalsrelative bioavailability (RBA)

Identifiers

PMID34092204
PMCPMC8390437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.