Evidence map›Paper›PMID 34092163›Full record

ArticleJournal of neurogenetics

Loss of mGluR1-LTD following cocaine exposure accumulates Ca

Hongyu Ruan, Wei-Dong Yao

Open access · greenAbstract read
In one paragraph

Article in Journal of neurogenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Inactivation of NMDAR and CaMKII signaling within the prelimbic cortex blocks incubated cocaine- and sucrose-craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Positive Allosteric Modulation of mGluBiological psychiatry · 2022
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hongyu RuanDepartment of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Wei-Dong YaoDepartment of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.
SUNY Upstate Medical University · US

Funding

ZETA CHAIN OF T CELL RECEPTOR INTERACTS W/ NEF OF SIV &HIV2P51RR000168 · NCRR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROWLETT, JAMES K · 1985 to 2011
$139.3M
Investigating Common Molecular Pathogenic Pathways in Frontotemporal Dementia Patients iPSC-Derived NeuronsR01NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2008 to 2026
$4.5M
Prefrontal AMPA receptors in FTD PathogenesisR01NS093097 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI GAO, FEN-BIAO, YAO, WEI-DONG · 2016 to 2020
$2.4M
Nonproteolytic Polyubiquitin Chains at the SynapseR01MH106489 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI YAO, WEI-DONG · 2015 to 2019
$2.1M
Dopaminergic Enabling of Synaptic Plasticity in Prefrontal CircuitsR01DA032283 · NIDA · UPSTATE MEDICAL UNIVERSITY · PI YAO, WEI-DONG · 2011 to 2015
$1.7M
NCRR NIH HHS P51 RR000168NIDA NIH HHS R01 DA032283NIMH NIH HHS R01 MH106489NINDS NIH HHS R01 NS057553NINDS NIH HHS R01 NS093097
6 · The paper itself

Abstract

Addiction results from drug-elicited alterations of synaptic plasticity mechanisms in dopaminergic reward circuits. Impaired metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) and accumulation of synaptic Ca

Indexed as

CocaineReceptors, Metabotropic GlutamateAnimalsMiceNeuronal PlasticityPrefrontal CortexReceptors, AMPACocainemetabotropic glutamate receptor type 1Receptors, AMPAReceptors, Metabotropic GlutamateAddictionlong-term depressionlong-term potentiationmetabotropic glutamate receptorsprefrontal cortexsynaptic plasticity

Identifiers

PMID34092163
PMCPMC9255266
OpenAlexW3166359807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.