Evidence map›Paper›PMID 34092096›Full record

Observational studyCirculation. Cardiovascular interventions2021

Correlation of Intravascular Ultrasound and Instantaneous Wave-Free Ratio in Patients With Intermediate Left Main Coronary Artery Disease.

Stephanie C El Hajj, Takumi Toya, Takayuki Warisawa, John Nan, Bradley R Lewis, Christopher M Cook, Christopher Rajkumar, James P Howard, Henry Seligman, Yousif Ahmad and 15 more

Open access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation. Cardiovascular interventions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 12 institutions in 3 countries.

Stephanie C El Hajj *Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (S.C.H., T.T., J.N., A.L.).
Takumi Toya *Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (S.C.H., T.T., J.N., A.L.).
Takayuki WarisawaNational Heart and Lung Institute, Imperial College London (T.W., C.M.C., C.R., J.P.H., H.S., Y.A., Y. Kikuta, J.E.D.).
John NanDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (S.C.H., T.T., J.N., A.L.).
Bradley R LewisDepartment of Biomedical Statistics and Informatics, Mao Clinic, Rochester, MN (B.R.L.).
Christopher M CookNational Heart and Lung Institute, Imperial College London (T.W., C.M.C., C.R., J.P.H., H.S., Y.A., Y. Kikuta, J.E.D.).
Christopher RajkumarNational Heart and Lung Institute, Imperial College London (T.W., C.M.C., C.R., J.P.H., H.S., Y.A., Y. Kikuta, J.E.D.).
James P HowardNational Heart and Lung Institute, Imperial College London (T.W., C.M.C., C.R., J.P.H., H.S., Y.A., Y. Kikuta, J.E.D.).
Henry SeligmanNational Heart and Lung Institute, Imperial College London (T.W., C.M.C., C.R., J.P.H., H.S., Y.A., Y. Kikuta, J.E.D.).
Yousif AhmadNational Heart and Lung Institute, Imperial College London (T.W., C.M.C., C.R., J.P.H., H.S., Y.A., Y. Kikuta, J.E.D.).
Shunichi DoiDivision of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan (S.D.).
Akihiro NakajimaDepartment of Cardiovascular Medicine, New Tokyo Hospital, Matsudo, Japan (A.N., S.N.).
Masafumi NakayamaCardiovascular Centre, Toda Central General Hospital, Japan (M.N.).
Sonoka GotoHospital Clínico San Carlos IDISSC, Complutense University of Madrid, Spain (S.G., R.V.-U., J.E.).
Rafael Vera-UrquizaHospital Clínico San Carlos IDISSC, Complutense University of Madrid, Spain (S.G., R.V.-U., J.E.).
Takao SatoDepartment of Cardiology, Tachikawa General Hospital, Nagaoka, Japan (S.G., T.S., Y. Kawase).
Yuetsu KikutaNational Heart and Lung Institute, Imperial College London (T.W., C.M.C., C.R., J.P.H., H.S., Y.A., Y. Kikuta, J.E.D.).
Yoshiaki KawaseDepartment of Cardiology, Tachikawa General Hospital, Nagaoka, Japan (S.G., T.S., Y. Kawase).
Hidetaka NishinaDepartment of Cardiology, Tsukuba Medical Center Hospital, Japan (H.N.).
Sunao NakamuraDepartment of Cardiovascular Medicine, New Tokyo Hospital, Matsudo, Japan (A.N., S.N.).
Hitoshi MatsuoDepartment of Cardiovascular Medicine, Gifu Heart Center, Japan (H.M.).
Javier EscanedHospital Clínico San Carlos IDISSC, Complutense University of Madrid, Spain (S.G., R.V.-U., J.E.).
Yoshihiro J Akashi
Justin E DaviesNational Heart and Lung Institute, Imperial College London (T.W., C.M.C., C.R., J.P.H., H.S., Y.A., Y. Kikuta, J.E.D.).
Amir LermanDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (S.C.H., T.T., J.N., A.L.).
Lung Institute · USHospital Clínico San Carlos · ESMayo Clinic · USTachikawa Medical Center · JPTwitter (United States) · USBradley Hospital · USKajima Corporation (Japan) · JPNew Tokyo Hospital · JPSt. Marianna University School of Medicine · JPTsukuba Medical Center Hospital · JPWaseda University · JPYokohama City Seibu Hospital · JP

Funding

Obesity-induced mesenchymal stem cell senescenceR01DK120292 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2019 to 2022
$2.6M
Quantitative magnetization transfer MRI for evaluation of renal fibrosisR01DK122734 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2023
$2.2M
Medical Research Council MR/S021108/1NIDDK NIH HHS R01 DK120292NIDDK NIH HHS R01 DK122734Wellcome Trust
6 · The paper itself

Abstract

backgroundThere is great degree of interobserver variability in the visual angiographic assessment of left main coronary disease (LMCD). Fractional flow reserve and intravascular ultrasound are often used in this setting. The use of instantaneous wave-free ratio (iFR) for evaluation of LMCD has not been well studied. The aim of this study is to evaluate the use of iFR in the assessment of angiographically intermediate LMCD.

methodsThis is an international multicenter retrospective observational study of patients who underwent both iFR and intravascular ultrasound evaluation for angiographically intermediate LMCD. An independent core laboratory performed blinded off-line analysis of all intravascular ultrasound data. A minimum lumen area of 6 mm2 was used as the cutoff for significant disease.

resultsOne hundred twenty-five patients (mean age, 68.4±9.5 years, 84.8% male) were included in this analysis. Receiver operating curve analysis showed that an iFR of ≤0.89 identified minimum lumen area <6 mm2 with an area under the curve of 0.77 (77% sensitivity, 66% specificity; P<0.0001). Among the 69 patients without ostial left anterior descending artery or left circumflex artery disease, receiver operating curve analysis showed that an iFR of ≤0.89 identified minimum lumen area <6 mm2 with an area under the curve of 0.84 (70% sensitivity, 84% specificity; P<0.0001). The correlation was not significantly different when the body surface area was considered.

conclusionsIn this study, in patients with intermediate LMCD, iFR of ≤0.89 correlates with intravascular ultrasound minimum lumen area <6 mm2 regardless of body surface area. The current study supports the use of iFR for the evaluation of intermediate LMCD.

Indexed as

Coronary Artery DiseaseFractional Flow Reserve, MyocardialAgedFemaleHumansMaleMiddle AgedUltrasonographyUltrasonography, Interventionalcoronary artery diseaseinstantaneous wave-free ratiointravascular ultrasound

Identifiers

PMID34092096
PMCPMC8206001
OpenAlexW3166673669

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.