Evidence map›Paper›PMID 34091770›Full record

ArticleHuman genetics2021

Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations.

Haojie Lu, Ting Wang, Jinhui Zhang, Shuo Zhang, Shuiping Huang, Ping Zeng

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Associations of Maternal Smoking During Pregnancy and Genetic Susceptibility with Incident Asthma from a Cohort Study.Prevention science : the official journal of the Society for Prevention Research · 2025
    Article
  4. Transfer Learning Prediction of Early Exposures and Genetic Risk Score on Adult Obesity in Two Minority Cohorts.Prevention science : the official journal of the Society for Prevention Research · 2025
    Article
  5. Article
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  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Haojie Lu *Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Ting Wang *Department of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Jinhui ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Shuo ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Shuiping HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Ping ZengDepartment of Epidemiology and Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. zpstat@xzhmu.edu.cn.ORCID http://orcid.org/0000-0003-2710-3440
Xuzhou Medical College · CN

Funding

the China Postdoctoral Science Foundation 2018M630607the China Postdoctoral Science Foundation 2019T120465the Natural Science Foundation of Jiangsu Province of China BK20181472the Postdoctoral Science Foundation of Xuzhou Medical University, the National Natural Science Foundation of China 81402765the QingLan Research Project of Jiangsu Province for Outstanding Young Teachers, the Six-Talent Peaks Project in Jiangsu Province of China WSN-087the Social Development Project of Xuzhou City KC19017the Social Development Project of Xuzhou City KC20062the Statistical Science Research Project from National Bureau of Statistics of China 2014LY112the Training Project for Youth Teams of Science and Technology Innovation at Xuzhou Medical University TD202008the Youth Foundation of Humanity and Social Science funded by Ministry of Education of China 18YJC910002
6 · The paper itself

Abstract

Genome-wide association studies (GWASs) have successfully identified a large amount of single-nucleotide polymorphisms associated with many complex phenotypes in diverse populations. However, a comprehensive understanding of the genetic correlation of associated loci of phenotypes across populations remains lacking and the extent to which associations discovered in one population can be generalized to other populations or can be utilized for trans-ethnic genetic prediction is also unclear. By leveraging summary statistics, we proposed MAGIC to evaluate the trans-ethnic marginal genetic correlation (r

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAsian PeopleBreast NeoplasmsFemaleGenome-Wide Association StudyHumansWhite People

Identifiers

PMID34091770
OpenAlexW3166269789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.