SynthesisEuropean journal of epidemiology2021
Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in European journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- DNA methylation and stroke prognosis: an epigenome-wide association study.Clinical epigenetics · 2024Pooled it
- Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women.Clinical epigenetics · 2022Trial
- Epigenome-Wide Association Study in Asian Cohort Identifies Novel DNA Methylation Markers for Carotid Intima-Media Thickness.Research square · 2026Article
- State-Dependent DNA Methylation Signatures Distinguish Acute from Stable Coronary Syndromes.International journal of molecular sciences · 2026Article
- Epigenome-Wide Association Study in Asian Cohort Identifies Novel DNA Methylation Markers for Carotid Intima-Media Thickness.medRxiv : the preprint server for health sciences · 2025Article
- Hypermethylation ofJournal of the American Heart Association · 2025Article
- Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study.BMC genomics · 2024Article
- Blood DNA methylation signature of diet quality and association with cardiometabolic traits.European journal of preventive cardiology · 2024Article
- Impact of high hemoglobin levels on carotid artery intima-media thickness and its predictive value for hypertension in high-altitude areas: a real-world study.Frontiers in cardiovascular medicine · 2024Article
- Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study.Scientific reports · 2023Article
- Biomarkers of Neurodegeneration in Post-Traumatic Stress Disorder: An Integrative Review.Biomedicines · 2023Review
- Epigenetics in Precision Nutrition.Journal of personalized medicine · 2022Review
- Ethical implications of epigenetics in the era of personalized medicine.Clinical epigenetics · 2022Review
- Reproductive history and blood cell DNA methylation later in life: the Young Finns Study.Clinical epigenetics · 2021Article
- Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study.Clinical epigenetics · 2021Article
- DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies.Clinical epigenetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors at 18 institutions in 5 countries.
Eliana Portilla-FernándezDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4105-8586
Shih-Jen HwangPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Rory WilsonResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Jane MaddockMRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.
W David HillCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Alexander TeumerIntitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Pashupati P MishraDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Roby JoehanesFramingham Heart Study, Framingham, MA, USA.
Symen LigthartDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Maryam KavousiDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Anton J M RoksDepartment of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus University Medical Center, Rotterdam, The Netherlands.
A H Jan DanserDepartment of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Daniel LevyPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Annette PetersResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Sahar GhasemiIntitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Ulf SchminkeDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Marcus DörrDZHK (German Centre for Cardiovascular Research), Partner Site Griefswald, Greifswald, Germany.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Mikko A HurmeDepartment of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Traci M BartzCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Joachim ThieryInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig, Leipzig, Germany.
Wolfgang KoenigDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Ken K OngMRC Epidemiology Unit and Department of Paediatrics, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Christine MeisingerIndependent Research Group, Clinical Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Joanna M WardlawCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Jochen SeisslerDiabetes Zentrum, Medizinische Klinik und Poliklinik IV - Campus Innenstadt, Klinikum Der Ludwig-Maximilians-Universität München, Munich, Germany.
Cornelia ThenDiabetes Zentrum, Medizinische Klinik und Poliklinik IV - Campus Innenstadt, Klinikum Der Ludwig-Maximilians-Universität München, Munich, Germany.
Wolfgang RathmannGerman Center for Diabetes Research, Neuherberg, Germany.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Henry VölzkeIntitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Christopher J O'DonnellCardiology Section and Center for Population Genomics, VA Boston Healthcare System, Boston, MA, USA.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. a.dehghan@imperial.ac.uk.
Erasmus MC · NLHelmholtz Zentrum München · DEUniversitätsmedizin Greifswald · DEUniversity of Washington · USTampere University · FIUniversity of Edinburgh · GBMRC Unit for Lifelong Health and Ageing · GBNational Institutes of Health · USDeutsches Diabetes-Zentrum e.V. · DEHarvard University · USKaiser Permanente Washington Health Research Institute · USKing's College London · GBTampere University Hospital · FIUK Dementia Research Institute · GBUniversität Ulm · DEUniversity Hospital Leipzig · DEUniversity of Cambridge · GBUniversity of Turku · FI
Funding
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MMedical Research Council G0700704Medical Research Council MC_UU_00006/2Medical Research Council MC_UU_00019/1Medical Research Council MC_UU_12015/2Medical Research Council MR/K026992/1Medical Research Council MR/T030852/1NHLBI NIH HHS R01 HL105756NHLBI NIH HHS U01 HL130114
Abstract
Common carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study (EWAS) of measures of cIMT in 6400 individuals. Mendelian randomization analysis was applied to investigate the potential causal role of DNA methylation in the link between atherosclerotic cardiovascular risk factors and cIMT or clinical cardiovascular disease. The CpG site cg05575921 was associated with cIMT (beta = -0.0264, p value = 3.5 × 10
Indexed as
Carotid Intima-Media ThicknessCoronary Artery DiseaseCross-Sectional StudiesEpigenomeHumansRisk FactorsCardiovascular risk factorsCommon carotid intima-media thicknessDifferentially methylated regionsDNA methylationEpigenome-wide association studiesMendelian randomizationVascular outcomes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.