Evidence map›Paper›PMID 34091704›Full record

ReviewRheumatology international2021

COVID-19 pneumonia in a patient with granulomatosis with polyangiitis on rituximab: case-based review.

Alicia Rodriguez-Pla, Holenarasipur R Vikram, Vanood Khalid, Lewis J Wesselius

Open access · hybridAbstract readCase ReportsReview
In one paragraph

Review in Rheumatology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. COVID-19 in patients with B cell immune deficiency.Journal of immunological methods · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Alicia Rodriguez-PlaDivision of Rheumatology, Mayo Clinic Arizona, Scottsdale, AZ, USA. rodriguezpla.alicia@mayo.edu.ORCID http://orcid.org/0000-0002-6255-5306
Holenarasipur R VikramDivision of Infectious Diseases, Mayo Clinic Arizona, Phoenix, AZ, USA.ORCID https://orcid.org/0000-0002-6391-0349
Vanood KhalidDivision of Hospital Internal Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA.
Lewis J WesseliusDivision of Pulmonary and Critical Care Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA.ORCID https://orcid.org/0000-0002-9013-6221
Mayo Clinic Hospital · USMayo Clinic in Arizona · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 77-year-old man with past medical history of granulomatosis with polyangiitis (GPA) on rituximab and prednisone, presented to the hospital with worsening cough and shortness of breath. He had tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by nasal swab polymerase chain reaction (PCR) while asymptomatic, 6 weeks earlier. He started with cough and shortness of breath 2 weeks after his initial positive test. After developing symptoms, he tested negative twice by nasal swab PCR, but the PCR of his bronchioloalveolar lavage was positive for SARS-CoV-2. He did not develop antibodies against coronavirus. Prednisone 15 mg daily was continued, and he received remdesivir, and convalescent plasma with quick recovery. We reviewed the literature to search for similar cases. Our case suggests that SARS-CoV-2 infection in patients on rituximab may have an atypical presentation and the diagnosis may be delayed due to negative PCR testing in the nasal swab. Patients may benefit from treatment with convalescent plasma.

Indexed as

AgedCOVID-19COVID-19 Drug TreatmentCOVID-19 SerotherapyGranulomatosis with PolyangiitisHost-Pathogen InteractionsHumansImmunization, PassiveImmunocompromised HostImmunosuppressive AgentsMaleRituximabSARS-CoV-2Treatment OutcomeImmunosuppressive AgentsRituximabAutoimmune rheumatic diseaseB cell depletionCOVID-19GPAGranulomatosis with polyangiitisImmunosuppressionImmunosuppressive treatmentRituximabSARS-CoV-2Vasculitis

Identifiers

PMID34091704
PMCPMC8180184
OpenAlexW3166692604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.