Evidence map›Paper›PMID 34091160›Full record

ArticleEnvironment international2021

Prenatal exposure to arsenic and lung function in children from the New Hampshire Birth Cohort Study.

Antonio J Signes-Pastor, Pablo Martinez-Camblor, Emily Baker, Juliette Madan, Margaret F Guill, Margaret R Karagas

Open access · goldAbstract read
In one paragraph

Article in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  11. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Antonio J Signes-PastorDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Pablo Martinez-CamblorBiomedical Data Science Department, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Emily BakerDepartment of Obstetrics & Gynecology, Division of Maternal Fetal Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States.
Juliette MadanDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States; Department of Pediatrics, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Margaret F GuillDepartment of Pediatrics, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States. Electronic address: margaret.r.karagas@dartmouth.edu.
Dartmouth College · USDartmouth–Hitchcock Medical Center · US

Funding

VARIATION IN BIOACCUMULATION AND BIOMAGNIFICATION OF METALS IN NORTHERN US LAKESP42ES007373 · NIEHS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 1995 to 2019
$52.0M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI SALAS DIAZ, LUCAS A · 2013 to 2022
$23.7M
Project 3: Placental Biomarkers of Exposure and Outcome (Marsit)P01ES022832 · NIEHS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2018
$4.7M
Training Program for Quantitative Population Sciences in CancerR25CA134286 · NCI · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA, TOSTESON, TOR D · 2009 to 2018
$3.0M
NCI NIH HHS R25 CA134286NIEHS NIH HHS P01 ES022832NIEHS NIH HHS P42 ES007373NIGMS NIH HHS P20 GM104416NIH HHS UH3 OD023275
6 · The paper itself

Abstract

Prenatal arsenic exposure is associated with an increased risk of lung cancer along with multiple non-carcinogenic outcomes, including respiratory diseases in arsenic-contaminated areas. Limited epidemiologic data exist on whether in utero arsenic exposure influences lung development and subsequent respiratory health. We investigated the association between gestational arsenic exposure and childhood lung function in the New Hampshire Birth Cohort Study. Urinary arsenic speciation including inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) and arsenobetaine was measured in maternal urine samples collected during pregnancy and spirometry was performed in offspring at a median age of 7.4 years. Forced vital capacity (FVC), forced expiratory volume in the first second of exhalation (FEV1), and forced expiratory flow between 25% and 75% of FVC (FEF25-75) standardized z-scores were assessed in linear models as dependent variables with the log

Indexed as

ArsenicPrenatal Exposure Delayed EffectsChildCohort StudiesEnvironmental ExposureFemaleHumansLungNew HampshirePregnancyArsenicArsenic speciationChildrenGestational exposureLung capacitySpirometry

Identifiers

PMID34091160
PMCPMC8353991
OpenAlexW3171481111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.