ArticleExperimental gerontology2021
Retinal vessel density correlates with cognitive function in older adults.
Article in Experimental gerontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Look into my eyes: What can eye-based measures tell us about the relationship between physical activity and cognitive performance?Journal of sport and health science · 2023Pooled it
- Observational
- Retinal vessel density and cognitive function in healthy older adults.Experimental brain research · 2025Article
- Early detection of mild cognitive impairment utilizing ocular biomarker-based risk scoring nomogram.Frontiers in aging neuroscience · 2025Article
- Retinal Microvasculature Changes Linked to Executive Function Impairment after COVID-19.Journal of clinical medicine · 2024Article
- OCTA: Essential or Gimmick?Ophthalmology and therapy · 2024Article
- Retinal Vascular Measurements and Mortality Risk: Evidence From the UK Biobank Study.Translational vision science & technology · 2024Article
- Development of a Novel Retina-Based Diagnostic Score for Early Detection of Major Depressive Disorder: An Interdisciplinary View.Frontiers in psychiatry · 2022Article
- Regional Homogeneity in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2022Article
- Using Optical Coherence Tomography to Screen for Cognitive Impairment and Dementia.Journal of Alzheimer's disease : JAD · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeWe examined the associations between retinal microvascular density, cognition, and physical fitness in healthy older adults with no reported cognitive decline.
methodsTwenty cognitively normal older adults (age: 70.3 ± 4.6 years) were recruited. Both eyes of each subject were imaged using optical coherence tomography angiography. The vessel densities of the retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP) were measured. Cognitive function was assessed using the Mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA), while physical performance was evaluated using the total work during the YMCA cycle ergometer test (TW-YMCA). Spearman correlations (r
resultsThe MoCA was significantly correlated to vessel density of SVD (r
conclusionsThis is the first study to reveal the association between retinal vessel density and cognition as measured with MoCA in healthy older adults with no reported cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.