Evidence map›Paper›PMID 34090937›Full record

ArticleNeuroscience letters2021

Hippocampal neurobiology and function in an aged mouse model of TDP-43 proteinopathy in an APP/PSEN1 background.

Sanaz Arezoumandan, Xuezhu Cai, Praveen Kalkarni, Stephani A Davis, Katherine Wilson, Craig F Ferris, Nigel J Cairns, Michael A Gitcho

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sanaz ArezoumandanDepartment of Biological Sciences, Delaware State University, Dover, DE, USA; Delaware Center for Neuroscience Research, Delaware State University, Dover, DE, USA.
Xuezhu CaiDepartments of Psychology and Pharmaceutical Sciences, Northeastern University, Boston, MA, USA; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Praveen KalkarniDepartments of Psychology and Pharmaceutical Sciences, Northeastern University, Boston, MA, USA; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Stephani A DavisDepartment of Biological Sciences, Delaware State University, Dover, DE, USA; Delaware Center for Neuroscience Research, Delaware State University, Dover, DE, USA.
Katherine WilsonDepartment of Biological Sciences, Delaware State University, Dover, DE, USA; Delaware Center for Neuroscience Research, Delaware State University, Dover, DE, USA.
Craig F FerrisDepartments of Psychology and Pharmaceutical Sciences, Northeastern University, Boston, MA, USA; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Nigel J CairnsCollege of Medicine and Health, University of Exeter, Exeter, UK.
Michael A GitchoDepartment of Biological Sciences, Delaware State University, Dover, DE, USA; Delaware Center for Neuroscience Research, Delaware State University, Dover, DE, USA. Electronic address: mgitcho@desu.edu.
Delaware State University · USNortheastern University · USUniversity of Exeter · GB

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
Updated confocal microscope in the Imaging Core facility to support biomedical researchP20GM103653 · NIGMS · DELAWARE STATE UNIVERSITY · PI HARRINGTON, MELISSA A · 2012 to 2022
$22.7M
Selective over expression of TDP-43 in APP/PS1 mice alters APP processingK01AG042500 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI GITCHO, MICHAEL ANDRE · 2013 to 2017
$679k
NIA NIH HHS K01 AG042500NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM103653
6 · The paper itself

Abstract

Aging is a major risk factor for Alzheimer's disease (AD), the most common cause of dementia worldwide. TDP-43 proteinopathy is reported to be associated with AD pathology is almost 50% of cases. Our exploratory study examined near end-stage (28 months old) mice selectively driving expression of human TDP-43 in the hippocampus and cortex in an APP/PSEN1 background. We hypothesized that hippocampal neuropathology caused by β-amyloidosis with TDP-43 proteinopathy induced in this model, resembling the pathology seen in AD cases, manifest with changes in resting state functional connectivity. In vivo magnetic resonance imaging and post-mortem histology were performed on four genotypes: wild type, APP/PSEN1, Camk2a/TDP-43, and Camk2a/TDP-43/APP/PSEN1. Our results revealed loss of functional coupling in hippocampus and amygdala that was associated with severe neuronal loss in dentate gyrus of Camk2a/TDP-43/APP/PSEN1 mice compared to APP/PSEN1 and wild type mice. The loss of cells was accompanied by high background of β-amyloid plaques with sparse phosphorylated TDP-43 pathology. The survival rate was also reduced in Camk2a/TDP-43/APP/PSEN1 mice compared to other groups. This end-of-life study provides exploratory data to reach a better understanding of the role of TDP-43 hippocampal neuropathology in diseases with co-pathologies of TDP-43 proteinopathy and β-amyloidosis such as AD and limbic predominant age-related TDP-43 encephalopathy (LATE).

Indexed as

AgingAlzheimer DiseaseAmygdalaAmyloid beta-Protein PrecursorAnimalsBrain MappingDisease Models, AnimalDNA-Binding ProteinsFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiceMice, TransgenicPresenilin-1Amyloid beta-Protein PrecursorAPP protein, humanDNA-Binding ProteinsPresenilin-1PSEN1 protein, humanTARDBP protein, humanAlzheimer’s diseaseLimbic predominant age-related TDP-43 encephalopathy (LATE)Network connectivityResting state BOLD functional connectivityTDP-43

Identifiers

PMID34090937
PMCPMC8237829
OpenAlexW3172665508

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.