ArticleThe Journal of pediatrics2021
Neonatal Cranial Ultrasound Findings among Infants Born Extremely Preterm: Associations with Neurodevelopmental Outcomes at 10 Years of Age.
Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Machine learning techniques for predicting neurodevelopmental impairments in premature infants: a systematic review.Frontiers in artificial intelligence · 2025Pooled it
- School-age outcomes of children after perinatal brain injury: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- Early predictors of cognitive trajectories from birth to adolescence in children born extremely preterm.Developmental medicine and child neurology · 2026Article
- Beyond Maximum Haemorrhage Grade: Serial Cranial Ultrasound Phenotyping Refines Developmental Risk Stratification After Intraventricular Haemorrhage in Very Preterm Infants.Journal of clinical medicine · 2026Article
- Three-Domain Serial Cranial Ultrasound Phenotypes and Outcomes in Very Preterm Infants with Severe Brain Injury: A Single-Center Cohort Study.Children (Basel, Switzerland) · 2026Article
- Neurodevelopmental forecasting in preterms: aEEG at 32 weeks vs. MRI at term in predicting 2-year outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Postmenstrual age-adjusted brain volumes and their association with early neurodevelopmental outcomes in very low birth weight infants.Scientific reports · 2026Article
- Extremely/Very Premature Birth Associated With Focal Epileptic Activity in Comorbid Autism and Epilepsy.Journal of child neurology · 2026Article
- Preterm Birth and Risk of Health Service Use, Morbidity, and Medication Needs at 5 Years.JAMA pediatrics · 2025Article
- Risk Factors for Autism Spectrum Disorder in Individuals Born Preterm: A Systematic Review and Meta-Analysis of Population-Based Studies.Biological psychiatry global open science · 2025Article
- Being born extremely preterm with low-grade intraventricular haemorrhage had no impact on brain volumes or neurodevelopment in later childhood.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Optimizing trajectories of social adaptive competencies after extreme prematurity during the first 1000 days.Seminars in fetal & neonatal medicine · 2024Review
- Child and family factors associated with positive outcomes among youth born extremely preterm.Pediatric research · 2023Article
- Review on the application of imaging examination for brain injury in premature infants.Frontiers in neurology · 2023Review
- Long-Term Outcome of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation.Pediatrics · 2022Article
- Early Ultrasonic Monitoring of Brain Growth and Later Neurodevelopmental Outcome in Very Preterm Infants.AJNR. American journal of neuroradiology · 2022Observational
- Extreme prematurity: Risk and resiliency.Current problems in pediatric and adolescent health care · 2022Review
- Placental transcriptional signatures associated with cerebral white matter damage in the neonate.Frontiers in neuroscience · 2022Article
- Alteration of the Oligodendrocyte Lineage Varies According to the Systemic Inflammatory Stimulus in Animal Models That Mimic the Encephalopathy of Prematurity.Frontiers in physiology · 2022Review
- A Consideration of Racism in Pediatric Epidemiologic Studies.The Journal of pediatrics · 2021Article
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Authors and funding
18 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association between neonatal cranial ultrasound (CUS) abnormalities among infants born extremely preterm and neurodevelopmental outcomes at 10 years of age. STUDY
designIn a multicenter birth cohort of infants born at <28 weeks of gestation, 889 of 1198 survivors were evaluated for neurologic, cognitive, and behavioral outcomes at 10 years of age. Sonographic markers of white matter damage (WMD) included echolucencies in the brain parenchyma and moderate to severe ventricular enlargement. Neonatal CUS findings were classified as intraventricular hemorrhage (IVH) without WMD, IVH with WMD, WMD without IVH, and neither IVH nor WMD.
resultsWMD without IVH was associated with an increased risk of cognitive impairment (OR 3.5, 95% CI 1.7, 7.4), cerebral palsy (OR 14.3, 95% CI 6.5, 31.5), and epilepsy (OR 6.9; 95% CI 2.9, 16.8). Similar associations were found for WMD accompanied by IVH. Isolated IVH was not significantly associated these outcomes.
conclusionsAmong children born extremely preterm, CUS abnormalities, particularly those indicative of WMD, are predictive of neurodevelopmental impairments at 10 years of age. The strongest associations were found with cerebral palsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.