Evidence map›Paper›PMID 34090485›Full record

ArticleStem cell research & therapy2021

WNT5A from the fetal liver vascular niche supports human fetal liver hematopoiesis.

Yoon Jung Choi, Adam M Heck, Brian J Hayes, Daniel Lih, Samuel G Rayner, Brandon Hadland, Ying Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. The evolving hematopoietic niche during development.Frontiers in molecular biosciences · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yoon Jung Choi *Department of Bioengineering, University of Washington, Seattle, WA, USA.
Adam M Heck *Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Brian J HayesClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Daniel LihDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Samuel G RaynerDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Brandon HadlandClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. bhadland@fredhutch.org.
Ying ZhengDepartment of Bioengineering, University of Washington, Seattle, WA, USA. yingzy@uw.edu.ORCID 0000-0003-2723-9022
University of Washington · USFred Hutch Cancer Center · USCalifornia Institute for Regenerative Medicine · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZA

Funding

Perfusable 3D human cardiac constructs for heart regenerationR01HL141570 · NHLBI · UNIVERSITY OF WASHINGTON · PI MURRY, CHARLES E, ZHENG, YING · 2018 to 2021
$3.3M
Niche signals in HSC genesisRC2DK114777 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERNSTEIN, IRWIN D, RAFII, SHAHIN · 2017 to 2021
$3.3M
A Microfluidic Bone Marrow Niche for the Study of HematopoiesisDP2DK102258 · NIDDK · UNIVERSITY OF WASHINGTON · PI ZHENG, YING · 2013 to 2013
$2.6M
Functional and transcriptional analysis of embryonic hematopoietic stem cell development at the single cell levelK08HL140143 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HADLAND, BRANDON K · 2018 to 2021
$584k
Constructing a Stem Cell Niche - Administrative SupplementF32DK102336 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HAYES, BRIAN JOSEPH · 2014 to 2017
$159k
NHLBI NIH HHS K08 HL140143NHLBI NIH HHS K08HL140143NHLBI NIH HHS R01HL141570NIDDK NIH HHS DP2 DK102258NIDDK NIH HHS F32 DK102336NIDDK NIH HHS F32DK102336NIDDK NIH HHS RC2 DK114777
6 · The paper itself

Abstract

The human fetal liver is a critical organ for prenatal hematopoiesis, the study of which offers insights into niche signals that regulate the fates of hematopoietic stem and progenitor cells (HSPCs) during fetal development. Here, we demonstrate that human fetal liver endothelium uniquely supports the maturation and expansion of multilineage HSPCs. Specifically, co-culture of fetal liver-derived immature CD43

Indexed as

Endothelial CellsHematopoiesisCell DifferentiationFemaleHematopoietic Stem CellsHumansLiverPregnancyWnt-5a ProteinWnt-5a ProteinWNT5A protein, humanFetal liver endotheliumHematopoiesisOrgan-specificWNT5A

Identifiers

PMID34090485
PMCPMC8180064
OpenAlexW3172575896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.