Evidence map›Paper›PMID 34090480›Full record

ReviewJournal of translational medicine2021

Translational precision medicine: an industry perspective.

Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Enrico Ferrero, Richard Siegel, Martin Fink, Sohail Ahmed, John Millholland and 4 more

Abstract readReview
In one paragraph

Review in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dominik HartlNovartis Institutes for BioMedical Research, Basel, Switzerland. dominik.hartl@novartis.com.
Valeria de LucaNovartis Institutes for BioMedical Research, Basel, Switzerland.
Anna KostikovaNovartis Institutes for BioMedical Research, Basel, Switzerland.
Jason LaramieNovartis Institutes for BioMedical Research, Cambridge, MA, USA.
Scott KennedyNovartis Institutes for BioMedical Research, Cambridge, MA, USA.
Enrico FerreroNovartis Institutes for BioMedical Research, Basel, Switzerland.
Richard SiegelNovartis Institutes for BioMedical Research, Basel, Switzerland.
Martin FinkNovartis Institutes for BioMedical Research, Basel, Switzerland.
Sohail Ahmed, Basel, Switzerland.
John MillhollandNovartis Precision Medicine, Cambridge, MA, USA.
Alexander SchuhmacherReutlingen University, Reutlingen, Germany.
Markus HinderNovartis Institutes for BioMedical Research, Basel, Switzerland.
Luca PialiRoche Innovation Center Basel, Basel, Switzerland.
Adrian RothRoche Innovation Center Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of how drugs are discovered, developed and marketed. Critical to this transformation is the adoption of new technologies in the drug development process, catalyzing the transition from serendipity-driven to data-driven medicine. This paradigm shift comes with a need for both translation and precision, leading to a modern Translational Precision Medicine approach to drug discovery and development. Key components of Translational Precision Medicine are multi-omics profiling, digital biomarkers, model-based data integration, artificial intelligence, biomarker-guided trial designs and patient-centric companion diagnostics. In this review, we summarize and critically discuss the potential and challenges of Translational Precision Medicine from a cross-industry perspective.

Indexed as

Artificial IntelligencePrecision MedicineBiomarkersDrug DiscoveryHumansTranslational Research, BiomedicalBiomarkersArtificial intelligenceBiomarkersCompanion diagnosticsDigital biomarkersDrug developmentModelingMulti-omicsPharmaceutical industryPrecision medicineTranslational medicine

Identifiers

PMID34090480
PMCPMC8179706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.