Evidence map›Paper›PMID 34090464›Full record

Trial reportJournal of cardiothoracic surgery2021

The effect of N-acetyl cysteine injection on renal function after coronary artery bypass graft surgery: a randomized double blind clinical trial.

Fatemeh Javaherforooshzadeh, Zahra Shaker, Mahboobeh Rashidi, Reza Akhondzadeh, Fatemeh Hayati

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cardiothoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Antioxidants for adults with chronic kidney disease.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Regulatory Effects of Astragaloside IV on Hyperglycemia-Induced Mitophagy in Schwann Cells.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fatemeh JavaherforooshzadehDepartment of anesthesia, Ahvaz Anesthesiology and Pain Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. f_javaherforoosh@yahoo.com.ORCID http://orcid.org/0000-0002-7687-5888
Zahra ShakerDepartment of anesthesia, Ahvaz Anesthesiology and Pain Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mahboobeh RashidiDepartment of anesthesia, Ahvaz Anesthesiology and Pain Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Reza AkhondzadehDepartment of anesthesia, Ahvaz Anesthesiology and Pain Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Fatemeh HayatiDepartment of Internal Medicine, School of Medicine. Chronic Renal Failure Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ahvaz Jundishapur University of Medical Sciences · IR

Funding

Ahvaz Jundishapur University of Medical Sciences PAIN-9817
6 · The paper itself

Abstract

backgroundThis study aimed to compare the effects of N-acetyl cysteine on renal function after coronary artery bypass graft surgery.

methodsIn this randomized clinical trial conducted in Golestan Hospital, Ahvaz, Iran, 60 candidates for coronary artery bypass graft surgery were selected and divided into two N-acetyl cysteine and control groups (30 people each). Patients received 3 (2 intraoperative and 1 postoperative) doses of IV N-acetyl cysteine (100 mg/kg) (n = 30) or placebo (n = 30) over 24 h. Prescription times were as follows: after induction of anesthesia, in the Next 4 h, and in the 16 h after on. Primary outcomes were serum levels of BUN and Cr, at baseline,4 and 48 h after surgery. And also need renal replacement therapy (RRT). Secondary outcomes included the hemodynamic variables, Blood products transfusion.

resultsThere were significant differences in BUN between groups at 4 h (P = 0.02) and 48 h after surgery (P = 0.001) There were significant differences in Cr level between groups at 4 h (P < 0.001) and 48 h after surgery (P = 0.001). MAP at different times (at 4 h p = 0.002 and 48 h after surgery P < 0.001) were significantly different between the two groups. There was a significant difference between the two groups in terms of the unit of Packed cell transfusion (P = 0.002) and FFP transfusion (P < 0.001).

conclusionIn the present study, we found that administration of N-acetyl cysteine can reduce the incidence of acute kidney injury in patients undergoing coronary artery bypass graft surgery and improved kidney functions. TRIAL REGISTRY: IRCT20190506043492N3 Registered at 2020.06.07.

Indexed as

Coronary Artery BypassAcetylcysteineAcute Kidney InjuryAdultAgedAntioxidantsDouble-Blind MethodDrug Administration ScheduleFemaleHumansInjections, IntravenousKidney Function TestsMaleMiddle AgedPerioperative CarePostoperative ComplicationsAcetylcysteineAntioxidantsAcute kidney injuryCoronary artery bypass graft surgeryN-acetyl-cysteine

Identifiers

PMID34090464
PMCPMC8180023
OpenAlexW3172667467

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.