ArticleBMC complementary medicine and therapies2021
Antibacterial, antifungal and antioxidant activities of whole plant chemical constituents of Rumex abyssinicus.
Article in BMC complementary medicine and therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- In vitro antimicrobial potential and phytochemical analysis of root extracts of Rumex abyssinicus from southern Ethiopia.PloS one · 2026Article
- Review
- Industrial Applications of Different Parts of FlatlandPlants (Basel, Switzerland) · 2025Article
- Evaluation of the Nephroprotective Activity of Crude Extract Root ofJournal of toxicology · 2025Article
- Study on the chemical composition and anti-fungi activities of anthraquinones and its glycosides from Rumex japonicus Houtt.Journal of natural medicines · 2024Article
- Preparation, Isolation and Antioxidant Function of Peptides from a New Resource ofFoods (Basel, Switzerland) · 2024Article
- The application of Rumex abyssinicus based activated carbon for Brilliant Blue Reactive dye adsorption from aqueous solution.BMC chemistry · 2023Article
- Antioxidant and Antibacterial Activities of the Leaf and Stem Extracts ofPlants (Basel, Switzerland) · 2023Article
- Phytochemical Composition ofPlants (Basel, Switzerland) · 2023Article
- Adsorption of methylene blue from textile industrial wastewater using activated carbon developed from Rumex abyssinicus plant.Scientific reports · 2023Article
- Triterpene and Steroids fromEvidence-based complementary and alternative medicine : eCAM · 2023Article
- The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review.Natural products and bioprospecting · 2022Review
- Overview of the Biological Activity of Anthraquinons and Flavanoids of the PlantMolecules (Basel, Switzerland) · 2022Review
- Marine fungi showing multifunctional activity against human pathogenic microbes and cancer.PloS one · 2022Article
- Antibacterial and Antioxidant Activities of Isolated Compounds fromInternational journal of analytical chemistry · 2022Article
- The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb-A Summary Update.International journal of molecular sciences · 2021Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntibiotic resistance has contributed to the burden of infectious diseases both in the hospital and community setting, and represents a great threat to public health. Previous studies have revealed the role of reactive oxygen species as intermediate mediators of tissue damage, following antibiotherapies, indicating the need of associating antioxidants to these treatments. Therefore, the present work was designed to study the antibacterial, antifungal and antioxidant activities of extracts and compounds from Rumex abyssinicus Jacq. (Polygonaceae), as well as to investigate the antibacterial mechanisms of action of the most effective agents.
methodsThe plant extracts were prepared by maceration in organic solvents followed by column chromatography of the EtOAc fraction and purification of different fractions which led to the isolation and characterization of pure compounds. The antimicrobial activities of the extracts/compounds and their combinations with ciprofloxacin and fluconazole were evaluated using the broth microdilution method by determining the minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC). The effects of the extracts on the bacterial cell membrane and microbial respiratory chain dehydrogenase enzyme activity were determined by spectrophotometric methods. Antioxidant activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and gallic acid equivalent antioxidant capacity (GAEAC) assays.
resultsChrysophanol (1), physcion (2), Ergosta-6,22-diene-3,5,8-triol (3), emodin (4), 6-hydroxyemodin (citreorosein) (5), chrysophanein (6) and physcionin (7) were isolated from EtOAc fraction of R. abyssinicus and displayed different degrees of antimicrobial activities (MIC = 8-256 μg/mL). The MeOH extract and compounds 2 and 4 exhibited synergistic effects with ciprofloxacin and fluconazole. Compounds 1, 2 and the combined mixture of 6 + 7 displayed the highest antioxidant activity (GAEAC = 83.38-106.03 μg/mL).
conclusionR. abyssinicus is a potential source of antibacterial, antifungal and antioxidant agents. The antibacterial mechanisms of action of the MeOH extract and compound 2 are due to disruption of the cytoplasmic membrane and inhibition of the microbial respiratory chain dehydrogenase enzyme activity. To the best of our knowledge, this is the first report of test samples and ciprofloxacin / fluconazole association against MDR strains. The observed activity of the isolated compounds against bacteria and fungi including MDR strains deserves further exploration.
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