Evidence map›Paper›PMID 34090374›Full record

ArticleBMC pediatrics2021

Prevalence and predictive factors of transient and permanent congenital hypothyroidism in Fars province, Iran.

Ashkan Habib, Alireza Shojazadeh, Mohadeseh Molayemat, Asadollah Habib, Marjan Jeddi, Rita Arabsolghar, Mitra Nahas, Nazila Rahimi, Fariba Moradi Ardekani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ashkan HabibSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Alireza ShojazadehSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohadeseh MolayematSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Asadollah HabibDepartment of Pediatric Endocrinology, School of Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
Marjan JeddiEndocrinology and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, P. O. Box: 71345-1414, Namazee Square, Shiraz, Iran. jedim@sums.ac.ir.
Rita ArabsolgharDepartment of Medical Laboratory Science, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Mitra NahasDeputy of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Nazila RahimiDeputy of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Fariba Moradi ArdekaniNon Communicable Disease Group, Office of Vice Chancellor for Health Affairs, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IRIslamic Azad University Kazeron · IR

Funding

Shiraz University of Medical Sciences 98-01-01-19685
6 · The paper itself

Abstract

introductionThere is no data on the number as well as the prevalence of congenital hypothyroidism (CH) in the Fars province. Hence, we designed this study to analyze the latest data and the possible predictive factors on transient and permanent CH in this province.

methodThis cross sectional study is based on the Fars province screening data from 2013 to 2016. A total of 294,214 newborns were screened with 938 confirmed cases of CH, which were included in this study. After recall and completion of the missing data, follow-up data for 642 CH cases with thyroid stimulating hormone (TSH) concentrations and levothyroxine doses for ten outpatient visits and final transient vs. permanent CH diagnosis were included.

resultsThe incidence rate was 1:313.66, and out of the 642 CH cases, 66.04 % had permanent CH, while 33.96 % had transient CH. TSH level trend during the outpatient visits were not statistically different between the two groups (P = 0.312). A cutoff point of > 2.25 levothyroxine µg/kg (sensitivity: 76.11 %, specificity: 58.52 %) at the third year and a TSH concentration of > 43.35 mIU/L at the venous sampling (initial TSH) (sensitivity: 31.66 %, specificity: 90.32 %) were the predictive factors for permanent CH.

conclusionFars province has one of the highest incidence rate of CH in Iran. Levothyroxine dose at the 3rd year and the 1st venous TSH sample are the predictive factors for permanent CH in the Iranian population; however, TSH concentrations during follow ups are unreliable predictors.

Indexed as

Congenital HypothyroidismCross-Sectional StudiesHumansInfant, NewbornIranNeonatal ScreeningPrevalenceThyrotropinThyrotropinCongenital HypothyroidismIranNewborn screeningThyroidThyroid-stimulating hormoneTransient vs. permanent congenital hypothyroidism

Identifiers

PMID34090374
PMCPMC8178910
OpenAlexW3138532985

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.