Evidence map›Paper›PMID 34090369›Full record

ArticleBMC pediatrics2021

A pilot study to evaluate the role of circulation CD4

Jingyang Li, Jinhong Wu, Haipei Liu, Li Hua, Quanhua Liu, Dingzhu Fang, Yi Chen, Ruoxu Ji, Jianhua Zhang, Wenwei Zhong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Stage-dependent interaction between circulating and tissue-resident memory CD4Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jingyang LiDepartment of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200090, Shanghai, China.
Jinhong WuDepartment of Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, 200127, Shanghai, China.
Haipei LiuDepartment of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200090, Shanghai, China.
Li HuaDepartment of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200090, Shanghai, China.
Quanhua LiuDepartment of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200090, Shanghai, China.
Dingzhu FangDepartment of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200090, Shanghai, China.
Yi ChenDepartment of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200090, Shanghai, China.
Ruoxu JiDepartment of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200090, Shanghai, China.
Jianhua ZhangDepartment of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200090, Shanghai, China. zhjh@163.com.
Wenwei ZhongDepartment of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200090, Shanghai, China. zhongwenwei@xinhuamed.com.cn.
Shanghai Jiao Tong University · CNXinHua Hospital · CN

Funding

National Natural Science Foundation of China 81270085Natural Science Foundation of Shanghai 17ZR1418000Shanghai Municipal Health Commission 202040164
6 · The paper itself

Abstract

backgroundWheezing is common in younger children and often related to viral infection. It is lack of reliable indicators for asthma prediction.

objectiveTo evaluate the relationship between circulation CD4

methodsA prospective study was performed in children under 5 years old presented with wheezing or at last one episode of documented wheezing history. After inclusion, the level of serum allergen-specific serum IgE (sIgE) and circulating CD4

resultsA total of 43 children completed follow-up. Higher wheezing frequency were found in children with asthma diagnosis. The mean of circulating CD4

conclusionsOur exploratory study shown that circulating CD4

Indexed as

AsthmaRespiratory SoundsCD4-Positive T-LymphocytesChildChild, PreschoolHumansPilot ProjectsProspective StudiesReceptors, CCR6CCR6 protein, humanReceptors, CCR6AsthmaCD4+CCR6+CRTh2+ memory Th2 cellChildrenWheezing

Identifiers

PMID34090369
PMCPMC8178821
OpenAlexW3167364807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.