ArticleBMC cardiovascular disorders2021
Different body parts' fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study.
Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 16 citations in OpenAlex.
- From Molecules to Machines: An Integrative Framework Linking Molecular Pathogenesis, Multi-Factorial Risk, Risk Stratification, Clinical Management, and Artificial Intelligence in QT Prolongation and Sudden Cardiac Death.Clinical cardiology · 2026Review
- Association between opium consumption and sarcopenia in middle-aged and older adults: findings from the Fasa Adults Cohort Study (FACS).Scientific reports · 2026Article
- New approaches to meta-analyze differences in skewness, kurtosis, and correlation.PLoS biology · 2026Article
- The Importance of Periodic Electrocardiograms in Individuals with Metabolic Disorders: A Policy Brief : Short title:Periodic ECG Monitoring in Metabolic Disorders.Galen medical journal · 2026Article
- The Effect of Obesity and General Anaesthesia Mode on the Frontal QRS-T Angle During Laparoscopic Surgery.Diagnostics (Basel, Switzerland) · 2025Article
- Association between body composition components and electrocardiogram parameters: results from the Fasa Adults Cohort Study (FACS).European journal of medical research · 2025Article
- The influence of gender and waist circumference in the association of body fat with cardiometabolic diseases.BMC nutrition · 2025Article
- The association between continuous metabolic syndrome score and its components with electrocardiographic abnormalities in community-dwelling older adults: the Bushehr elderly health (BEH) program.BMC cardiovascular disorders · 2024Article
- Age and gender differences of basic electrocardiographic values and abnormalities in the general adult population; Tehran Cohort Study.BMC cardiovascular disorders · 2023Article
- The Relationship between Body Composition and ECG Ventricular Activity in Young Adults.International journal of environmental research and public health · 2022Article
- Predictive value of clinical examination parameters for cardiovascular adverse events during treatment of chronic myeloid leukemia with tyrosine kinase inhibitors.International journal of hematology · 2022Article
- The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study.BMC cardiovascular disorders · 2022Article
- The Fasa Registry on Systolic Heart Failure (FaRSH): Feasibility Study and the First 5-year Reports.Galen medical journal · 2021Article
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies suggested that obesity and fat mass are associated with QT interval prolongation, but the role of different body parts' fat mass is unclear. The associations between total and regional fat mass (FM) and corrected QT interval (QTc) were investigated for the first time in this study.
methodsIn this sub-analysis of Fasa PERSIAN cohort Study data, 3217 subjects aged 35-70 entered our study. Body fat mass was assessed by bioelectrical impedance analysis and QTc interval calculated by the QT interval measured by Cardiax
resultsIn males, the fat mass to fat-free mass (FM/FFM) ratio in the trunk, arms, total body, and legs were significantly higher in the prolonged QTc group (QTc > 450 ms). Trunk (B = 0.148), total (B = 0.137), arms (B = 0.124), legs (B = 0.107) fat mass index (FMI) showed significant positive relationship with continuous QTc (P-value < 0.001). Also, just the fat-free mass index of legs had significant positive associations with QTc interval (P-value < 0.05). Surprisingly, in females, the mean of FM/FFM ratio in trunk and legs in the normal QTc group had higher values than the prolonged QTc group (QTc > 470 ms). Also, none of the body composition variables had a significant correlation with continuous QTc.
conclusionOur study suggested that FMI ratios in the trunk, total body, arms, and legs were positively associated with QTc interval in males, respectively, from a higher to a lower beta-coefficient. Such associations were not seen in females. Our study implies that body fat mass may be an independent risk factor for higher QTc interval and, consequently, more cardiovascular events that should be investigated.
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