Evidence map›Paper›PMID 34090124›Full record

ArticleNeuroImage. Clinical2021

TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy.

Daniele Bertoglio, Halima Amhaoul, Joery Goossens, Idrish Ali, Elisabeth Jonckers, Tom Bijnens, Matteo Siano, Leonie Wyffels, Jeroen Verhaeghe, Annemie Van der Linden and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Astrocytic CaGlia · 2024
    Article
  5. Translocator protein (18 kDa) positron emission tomography imaging as a biomarker of neuroinflammation in epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
  6. Review
  7. Review
  8. Evaluation ofJournal of clinical medicine · 2022
    Article
  9. Article
  10. [European journal of nuclear medicine and molecular imaging · 2022
    Article
  11. What value can TSPO PET bring for epilepsy treatment?European journal of nuclear medicine and molecular imaging · 2021
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Daniele BertoglioMolecular Imaging Center Antwerp, University of Antwerp, Belgium; Department of Translational Neurosciences, University of Antwerp, Belgium. Electronic address: daniele.bertoglio@uantwerpen.be.
Halima AmhaoulDepartment of Translational Neurosciences, University of Antwerp, Belgium.
Joery GoossensDepartment of Translational Neurosciences, University of Antwerp, Belgium.
Idrish AliDepartment of Translational Neurosciences, University of Antwerp, Belgium.
Elisabeth JonckersBio-Imaging Lab, University of Antwerp, Belgium.
Tom BijnensDepartment of Translational Neurosciences, University of Antwerp, Belgium.
Matteo SianoDepartment of Translational Neurosciences, University of Antwerp, Belgium.
Leonie WyffelsMolecular Imaging Center Antwerp, University of Antwerp, Belgium; Department of Nuclear Medicine, Antwerp University Hospital, Edegem, Belgium.
Jeroen VerhaegheMolecular Imaging Center Antwerp, University of Antwerp, Belgium.
Annemie Van der LindenBio-Imaging Lab, University of Antwerp, Belgium.
Steven StaelensDepartment of Translational Neurosciences, University of Antwerp, Belgium.
Stefanie DedeurwaerdereLaboratory of Experimental Hematology, University of Antwerp, Belgium.
University of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation is a key component of epileptogenesis, the process leading to acquired epilepsy. In recent years, with the development of non-invasive in vivo positron emission tomography (PET) imaging of translocator protein 18 kDa (TSPO), a marker of neuroinflammation, it has become possible to perform longitudinal studies to characterize neuroinflammation at different disease stages in animal models of epileptogenesis. This study aimed to utilize the prognostic capability of TSPO PET imaging at disease onset (2 weeks post-SE) to categorize epileptic rats with distinct seizure burden based on TSPO levels at disease onset and investigate their association to TSPO expression at the chronic epilepsy stage. Controls (n = 14) and kainic acid-induced status epilepticus (KASE) rats (n = 41) were scanned non-invasively with [

Indexed as

Epilepsy, Temporal LobeAnimalsBrainCarrier ProteinsDisease Models, AnimalMolecular ImagingPhenotypePositron-Emission TomographyRatsReceptors, GABA-AUp-RegulationCarrier ProteinsReceptors, GABA-ATspo protein, ratInflammationKainic acidKASENeuroimagingPET imagingTranslocator protein

Identifiers

PMID34090124
PMCPMC8182303
OpenAlexW3168370642

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.