Evidence map›Paper›PMID 34089978›Full record

ArticleBiophysical chemistry2021

A computational evaluation of targeted oxidation strategy (TOS) for potential inhibition of SARS-CoV-2 by disulfiram and analogues.

Luyan Xu, Jiahui Tong, Yiran Wu, Suwen Zhao, Bo-Lin Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Biofilm · 2023
    Article
  2. Disulfiram: Mechanisms, Applications, and Challenges.Antibiotics (Basel, Switzerland) · 2023
    Review
  3. Article
  4. An overview of potential inhibitors targeting non-structural proteins 3 (PLComputational and structural biotechnology journal · 2021
    Review
  5. Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review).International journal of molecular medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Luyan XuSchool of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Jiahui TongiHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yiran WuiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Suwen ZhaoiHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: zhaosw@shanghaitech.edu.cn.
Bo-Lin LinSchool of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: linbl@shanghaitech.edu.cn.
Chinese Academy of Sciences · CNShanghaiTech University · CNShanghai Institute of Organic Chemistry · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the new millennium, the outbreak of new coronavirus has happened three times: SARS-CoV, MERS-CoV, and SARS-CoV-2. Unfortunately, we still have no pharmaceutical weapons against the diseases caused by these viruses. The pandemic of SARS-CoV-2 reminds us the urgency to search new drugs with totally different mechanism that may target the weaknesses specific to coronaviruses. Herein, we disclose a computational evaluation of targeted oxidation strategy (TOS) for potential inhibition of SARS-CoV-2 by disulfiram, a 70-year-old anti-alcoholism drug, and predict a multiple-target mechanism. A preliminary list of promising TOS drug candidates targeting the two thiol proteases of SARS-CoV-2 are proposed upon virtual screening of 32,143 disulfides.

Indexed as

Alcohol DeterrentsAntiviral AgentsCatalytic DomainCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesCOVID-19 Drug TreatmentDisulfiramDrug RepositioningGene ExpressionHumansKineticsMolecular Docking SimulationOxidation-ReductionProtease InhibitorsProtein BindingProtein Interaction Domains and MotifsAlcohol DeterrentsAntiviral AgentsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesDisulfirampapain-like protease, SARS-CoV-2Protease InhibitorsCoronavirusCOVID-19DisulfideSARS-CoV-2Target oxidation strategyThiol protease

Identifiers

PMID34089978
PMCPMC8161800
OpenAlexW3172607736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.