Evidence map›Paper›PMID 34089950›Full record

ArticlePublic health2021

Survival in adult pneumonia inpatients fulfilling suspected COVID-19 criteria and baseline negative RT-qPCR.

E Murillo-Zamora, O Mendoza-Cano, M I Cárdenas-Rojas, C M Hernandez-Suarez, J Guzmán-Esquivel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. [Survival in pediatric patients with pneumonia in coronavirus disease 2019].Revista medica del Instituto Mexicano del Seguro Social · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E Murillo-ZamoraDepartamento de Epidemiología, Unidad de Medicina Familiar No. 19, Instituto Mexicano del Seguro Social, Av. Javier Mina 301, Col. Centro, C.P. 28000, Colima, Colima, Mexico; Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Col. Las Víboras, C.P. 28040, Colima, Colima, Mexico. Electronic address: efren.murilloza@imss.gob.mx.
O Mendoza-CanoFacultad de Ingeniería Civil, Universidad de Colima, km. 9 carretera Colima-Coquimatlán, C.P. 28400, Coquimatlán, Colima, Mexico. Electronic address: oliver@ucol.mx.
M I Cárdenas-RojasCoordinación de Investigación en Salud, Jefatura de Servicios de Prestaciones Médicas, Instituto Mexicano del Seguro Social, Doroteo López No. 442 Col. Magisterial, C.P. 28030, Colima, Colima, Mexico. Electronic address: martha.cardenasr@imss.gob.mx.
C M Hernandez-SuarezFacultad de Ciencias, Universidad de Colima, Bernal Díaz del Castillo 340, Col. Villas San Sebastián, C.P. 28045, Mexico. Electronic address: carlosmh@mac.com.
J Guzmán-EsquivelFacultad de Medicina, Universidad de Colima, Av. Universidad 333, Col. Las Víboras, C.P. 28040, Colima, Colima, Mexico; Unidad de Investigación en Epidemiología Clínica, Instituto Mexicano del Seguro Social, Av. De Los Maestros 149, Col. Centro, C.P. 28030, Colima, Colima, Mexico. Electronic address: pepeguzman_esquivel@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe objective of this study was to evaluate the survival experience of suspicion COVID-19 hospitalized patients with pneumonia and negative baseline reverse-transcription quantitative polymerase chain reaction (RT-qPCR) test results. STUDY

designWe conducted a nationwide retrospective cohort study in Mexico.

methodsAdult pneumonia inpatients fulfilling suspected COVID-19 criteria, and hospital entry from March to August 2020, were enrolled. The Kaplan-Meier method was to use to compare survival estimates among patients with negative RT-qPCR nasopharyngeal or oropharyngeal swabs and those with a baseline positive test.

resultsData from 64,624 individuals fulfilling suspected COVID-19 criteria were analyzed and 1.6% of them had negative RT-qPCR tests. The overall mortality rate was higher among laboratory-positive patients (48.5% vs. 34.2%, P < 0.001) and, at any given threshold, the survival estimates were higher among RT-qPCR-negative pneumonia inpatients.

conclusionsThe pathogenic mechanism of COVID-19 remains poorly understood and suspected cases with pneumonia and negative laboratory results represent a major challenge for healthcare systems. Our findings suggest that RT-qPCR-negative inpatients may have an improved disease prognosis, but the in-hospital mortality was still high among them. However, further research is needed to clarify the clinical and epidemiological implications of our results.

Indexed as

AdultAgedCOVID-19COVID-19 TestingFemaleHumansInpatientsMaleMexicoMiddle AgedPneumoniaRetrospective StudiesReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2Cohort studiesCOVID-19PrognosisReverse transcriptase polymerase chain reactionSevere acute respiratory syndrome coronavirus 2

Identifiers

PMID34089950
PMCPMC8098043

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.