Observational studyChest2021
Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States: The Severe ARDS: Generating Evidence Study.
Registry-linked trialAbstract readObservational Study
In one paragraph
Observational study in Chest, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03021824 (Severe ARDS), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Severe ARDS: Generating Evidence. A U.S. Multicenter Observational Study.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2024Guideline
- Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial.Chest · 2025Trial
- ARDS management beyond the guidelines: a practical physiology-based approach to individualized care.Intensive care medicine · 2026Review
- ARDS and corticosteroids: beyond COVID-19.Pneumonia (Nathan Qld.) · 2026Review
- ICU Implementation Determinants and Delivery of Lung Protective Ventilation: A Multihospital Survey and Cohort Study.CHEST critical care · 2026Article
- Enhanced mortality prediction in pneumonia-associated acute respiratory distress syndrome: a model integrating lymphocyte subsets with clinical parameters in non-immunosuppressed adults.Frontiers in medicine · 2026Article
- Take a deep breath: managing the challenges of acute respiratory distress syndrome cases.Trauma surgery & acute care open · 2026Review
- Review
- Development and External Validation of a Detection Model to Retrospectively Identify Patients With Acute Respiratory Distress Syndrome.Critical care medicine · 2025Article
- The implementation gap in critical care: From nutrition to ventilation.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Impact of board-certified intensive care training facilities on choice of adjunctive therapies and prognosis of severe respiratory failure: a nationwide cohort study.Journal of intensive care · 2024Article
- Prone Positioning: What Remains to Be Learned after Decades of Clinical Trials.Annals of the American Thoracic Society · 2024Article
- Extended versus Standard Proning Duration for COVID-19-associated Acute Respiratory Distress Syndrome: A Target Trial Emulation Study.Annals of the American Thoracic Society · 2024Article
- Comparing the impact of targeting limited driving pressure to low tidal volume ventilation on mortality in mechanically ventilated adults with COVID-19 ARDS: an exploratory target trial emulation.BMJ open respiratory research · 2024Article
- IBR1, a novel endogenous IFIH1-binding dsRNA, governs IFIH1 activation and M1 macrophage polarisation in ARDS.Clinical and translational medicine · 2024Article
- Management of severe acute respiratory distress syndrome in Australia and New Zealand (SAGE-ANZ): An observational study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Lung Protective Ventilation Adherence and Outcomes for Patients With COVID-19 Acute Respiratory Distress Syndrome Treated in an Intermediate Care Unit Repurposed to ICU Level of Care.Critical care explorations · 2024Observational
- 21st century critical care medicine: An overview.World journal of critical care medicine · 2024Review
- Protocol and Statistical Analysis Plan for the Mode of Ventilation During Critical Illness (MODE) Trial.CHEST critical care · 2024Article
- Article
Corrections and comments
- Commented on by
Authors and funding
38 authors.
Nida QadirDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
Raquel R BartzDivision of Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC.
Mary L CooterDivision of Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC.
Catherine L HoughDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health and Science University, Portland, OR.
Michael J LanspaDivision of Pulmonary Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT; Intermountain Medical Center, Murray, UT.
Valerie M Banner-GoodspeedDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Jen-Ting ChenDivision of Critical Care Medicine, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY.
Shewit GiovanniDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA.
Dina GomaaDepartment of Surgery, University of Cincinnati Medical Center, Cincinnati, OH.
Michael W SjodingDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Negin HajizadehDivision of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY.
Jordan KomisarowDepartment of Emergency Medicine, Temple University Hospital, Philadelphia, PA; Department of Neurosurgery, Duke University Medical Center, Durham, NC.
Abhijit DuggalDepartment of Critical Care Medicine, Cleveland Clinic, Cleveland, OH.
Ashish K KhannaSection of Critical Care Medicine, Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC; Outcomes Research Consortium, Cleveland, OH.
Rahul KashyapDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.
Akram KhanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health and Science University, Portland, OR.
Steven Y ChangDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
Joseph E TonnaDivisions of Cardiothoracic Surgery and Emergency Medicine, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT.
Harry L AndersonDepartment of Surgery, St. Joseph Mercy Hospital, Ann Arbor, MI.
Janice M LieblerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Jarrod M MosierDepartment of Emergency Medicine, University of Arizona College of Medicine, Tucson, AZ.
Peter E MorrisDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY.
Alissa GenthonDepartment of Critical Care Medicine, Mayo Clinic, Scottsdale, AZ.
Irene K LouhDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY; New York-Presbyterian Hospital.
Mark TidswellDivision of Pulmonary and Critical Care Medicine Baystate Medical Center and University of Massachusetts Medical School, Springfield, MA.
R Scott StephensDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Annette M EsperDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
David J DriesDepartment of Surgery, Regions Medical Center, St. Paul, MN.
Anthony MartinezDivision of Critical Care, St. Agnes Hospital, Baltimore, MD.
Kraftin E SchreyerDepartment of Emergency Medicine, Temple University Hospital, Philadelphia, PA.
William BenderDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
Anupama TiwariDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Albany Medical College, Albany, NY.
Pramod K GuruDivision of Critical Care Medicine, Department of Medicine, Mayo Clinic, Jacksonville, FL.
Sinan HannaDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI.
Michelle N GongDivision of Critical Care Medicine, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY.
Pauline K ParkDivision of Acute Care Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI. Electronic address: parkpk@med.umich.edu.
Severe ARDS: Generating Evidence (SAGE) Study Investigators
Society of Critical Care Medicine's Discovery Network
Funding
Wake Forest Clinical and Translational Science AwardKL2TR001421 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MILLER, DAVID P · 2015 to 2023
$5.8MOptimizing Selection and Management of Cardiac Arrest Patients Treated with ECMOK23HL141596 · NHLBI · UNIVERSITY OF UTAH · PI TONNA, JOSEPH EDWARD · 2018 to 2022
$945kData-Driven Identification of the Acute Respiratory Distress SyndromeK01HL136687 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SJODING, MICHAEL WILLIAM · 2017 to 2021
$862kNCATS NIH HHS KL2 TR001421NHLBI NIH HHS K01 HL136687NHLBI NIH HHS K23 HL141596
Abstract
backgroundAlthough specific interventions previously demonstrated benefit in patients with ARDS, use of these interventions is inconsistent, and patient mortality remains high. The impact of variability in center management practices on ARDS mortality rates remains unknown. RESEARCH QUESTION: What is the impact of treatment variability on mortality in patients with moderate to severe ARDS in the United States? STUDY DESIGN AND
methodsWe conducted a multicenter, observational cohort study of mechanically ventilated adults with ARDS and Pao
resultsA total of 2,466 patients were enrolled. Median baseline Pao
interpretationSubstantial center-to-center variability exists in ARDS management, suggesting that further opportunities for improving ARDS outcomes exist. Early adherence to LPV was associated with lower center mortality and may be a surrogate for overall quality of care processes. Future collaboration is needed to identify additional treatment-level factors influencing center-level outcomes. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT03021824; URL: www.clinicaltrials.gov.
Indexed as
Hospital MortalityAdultAgedCohort StudiesEarly Medical InterventionExtracorporeal Membrane OxygenationFemaleGlucocorticoidsGuideline AdherenceHumansMaleMiddle AgedNeuromuscular BlockadePatient PositioningPositive-Pressure RespirationPractice Guidelines as TopicGlucocorticoidsVasodilator AgentsARDScorticosteroidsextracorporeal membrane oxygenationmechanical ventilationneuromuscular blockadeprone positioning
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT03021824ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.