ArticleNeuron2021
CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells.
Open access · greenAbstract read
In one paragraph
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- A meta-analysis of genome-wide studies of resilience in the German population.Molecular psychiatry · 2025Pooled it
- Rescue of stereocilia architecture and hearing function by AAV-CIB2 and AAV-CIB3 in a mouse model of recessive deafness DFNB48.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- CaProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Molecular identity of the mechanotransduction machinery in inner ear hair cells and mechanotransduction-linked hearing loss.Fundamental research · 2026Review
- Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tonotopic specialization of MYO7A isoforms in auditory hair cells.Nature communications · 2026Article
- Examining the role of lipids in hearing.eLife · 2026Article
- Evolutionary tuning of an auditory transduction channel.Current biology : CB · 2026Article
- The protocadherin-15-LHFPL5 tip link complex is a heterotetrameric assembly in hair cell stereocilia.Biophysical journal · 2026Article
- Lipid Regulation of Mechanosensitive Ion Channels.International journal of molecular sciences · 2026Review
- Altered Pore Composition and Flexibility in a Deafness-Associated TMC1 Variant: Insights from Molecular Dynamics Simulations.ACS chemical neuroscience · 2025Article
- LHFPL5 is required for maximal activation of the mechanotransduction channel in cochlear hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identification of druggable binding sites and small molecules as modulators of TMC1.Communications biology · 2025Article
- A force-sensitive adhesion GPCR is required for equilibrioception.Cell research · 2025Article
- Ankyrins are dispensable for mechanotransduction by cochlear hair cells.Hearing research · 2025Article
- CIB2 function is distinct from that of whirlin in the organization of sterocilia architecture.Disease models & mechanisms · 2025Article
- The Diverse Functions of the Calcium- and Integrin-Binding Protein Family.International journal of molecular sciences · 2025Review
- Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction.Communications biology · 2025Article
- Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans.Nature communications · 2025Article
- Differentially Expressed Genes in Cardiomyocytes of the First Camelized Mouse Model, NrapGenes · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Xiaoping LiangThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Xufeng QiuThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Gilman DionneDepartment of Biochemistry and Molecular Biophysics, Zuckerman Mind Brain, Department of Systems Biology, Columbia University, New York, NY 10032, USA.
Christopher L CunninghamThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Michele L PucakThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Guihong PengThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ye-Hyun KimDepartment of Otolaryngology-HNS, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Amanda LauerDepartment of Otolaryngology-HNS, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lawrence ShapiroDepartment of Biochemistry and Molecular Biophysics, Zuckerman Mind Brain, Department of Systems Biology, Columbia University, New York, NY 10032, USA. Electronic address: lawrenceshapiro@gmail.com.
Ulrich MüllerThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: umuelle3@jhmi.edu.
Johns Hopkins University · USColumbia University · US
Funding
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2MMechanosensor Development, Function, and DysfunctionR01DC005965 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI MUELLER, ULRICH · 2003 to 2023
$10.2MMouse models to study inherited forms of deafnessR01DC007704 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI MUELLER, ULRICH · 2005 to 2014
$5.0MIntegrative Structural and Functional Characterization of Tip-Link Cadherins DeafnessR01DC016960 · NIDCD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MUELLER, ULRICH, SHAPIRO, LAWRENCE S · 2018 to 2022
$3.3MPhysiology and Pathophysiology of Interactions between Hair Cells and Neurons.R01DC014713 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI MUELLER, ULRICH · 2015 to 2019
$2.5MMechanisms of Protein Assembly and Transport in Hair CellsR21DC019195 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUNNINGHAM, CHRISTOPHER L · 2021 to 2023
$477kContribution of COMT2 to auditory processing in mammalian sensory hair cellsF32DC015724 · NIDCD · SCRIPPS RESEARCH INSTITUTE, THE · PI CUNNINGHAM, CHRISTOPHER L · 2016 to 2018
$184kNIDCD NIH HHS F32 DC015724NIDCD NIH HHS R01 DC005965NIDCD NIH HHS R01 DC007704NIDCD NIH HHS R01 DC014713NIDCD NIH HHS R01 DC016960NIDCD NIH HHS R21 DC019195NIGMS NIH HHS P30 GM124165
Abstract
CIB2 is a Ca
Indexed as
AnimalsCalcium-Binding ProteinsCrystallography, X-RayHair Cells, AuditoryHEK293 CellsHumansKv Channel-Interacting ProteinsMechanotransduction, CellularMembrane ProteinsMiceMice, Inbred C57BLMice, TransgenicCalcium-Binding ProteinsCIB2 protein, humanCIB3 protein, humanKv Channel-Interacting ProteinsMembrane ProteinsTMC1 protein, humanTMC2 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.