Evidence map›Paper›PMID 34089556›Full record

ArticleAngewandte Chemie (International ed. in English)2021

A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing*.

Sarah H Gardner, Catharine J Brady, Cameron Keeton, Anuj K Yadav, Sharath C Mallojjala, Melissa Y Lucero, Shengzhang Su, Zhengxin Yu, Jennifer S Hirschi, Liviu M Mirica and 1 more

Open access · greenAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 113 citations in OpenAlex.

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  15. Near-Infrared Dyes: Towards Broad-Spectrum Antivirals.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Article
  18. A long-wavelength xanthene dye for photoacoustic imaging.Chemical communications (Cambridge, England) · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sarah H GardnerDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.ORCID 0000-0002-9356-7190
Catharine J BradyDepartment of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, I, L, 61801, USA.ORCID 0000-0003-4232-6191
Cameron KeetonDepartment of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, I, L, 61801, USA.ORCID 0000-0001-9889-2374
Anuj K YadavDepartment of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, I, L, 61801, USA.ORCID 0000-0002-4736-4392
Sharath C MallojjalaDepartment of Chemistry, Binghamton University, Binghamton, NY, 13902, USA.
Melissa Y LuceroDepartment of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, I, L, 61801, USA.ORCID 0000-0002-7221-1144
Shengzhang SuDepartment of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, I, L, 61801, USA.ORCID 0000-0003-3808-4863
Zhengxin YuDepartment of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, I, L, 61801, USA.ORCID 0000-0002-3592-9704
Jennifer S HirschiDepartment of Chemistry, Binghamton University, Binghamton, NY, 13902, USA.
Liviu M MiricaDepartment of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, I, L, 61801, USA.
Jefferson ChanDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.ORCID 0000-0003-4139-4379
University of Illinois Urbana-Champaign · USBinghamton University · US

Funding

Training Program at the Chemistry Biology InterfaceT32GM136629 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Paul Hergenrother · 2020 to 2026
$4.5M
Chemical Tools to Study the Role of Biological AldehydesR35GM133581 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Jefferson Chan · 2019 to 2026
$3.1M
NOVEL BIFUNCTIONAL CHEMICAL AGENTS AS THERANOSTIC TOOLS FOR AMYLOID DISEASESR01GM114588 · NIGMS · WASHINGTON UNIVERSITY · PI MIRICA, LIVIU M. · 2015 to 2019
$1.4M
Mechanistic Investigation into Photoredox CatalysisR15GM142103 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI HIRSCHI, JENNIFER · 2021 to 2021
$466k
Foundation for the National Institutes of Health R01GM114588Foundation for the National Institutes of Health R15GM142103-01Foundation for the National Institutes of Health R35GM133581NIGMS NIH HHS R01 GM114588NIGMS NIH HHS R15 GM142103NIGMS NIH HHS R35 GM133581NIGMS NIH HHS T32 GM136629
6 · The paper itself

Abstract

Most photoacoustic (PA) imaging agents are based on the repurposing of existing fluorescent dye platforms that exhibit non-optimal properties for PA applications. Herein, we introduce PA-HD, a new dye scaffold optimized for PA probe development that features a 4.8-fold increase in sensitivity and a red-shift of the λ

Indexed as

Optical ImagingPhotoacoustic TechniquesAlzheimer DiseaseAnimalsBrainCarbocyaninesDisease Models, AnimalFluorescent DyesHydrogen PeroxideMiceMolecular StructureOxidative StressCarbocyaninesFluorescent DyesHydrogen Peroxidetetramethylene hemicyanineacoustogenic probeAlzheimer's diseaseanalyte sensinghydrogen peroxidephotoacoustic imaging

Identifiers

PMID34089556
PMCPMC8550804
OpenAlexW3162020708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.