Evidence map›Paper›PMID 34089513›Full record

ArticlePharmacological reports : PR2021

The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients.

Zhaolin Chen, Xi Cheng, Liwen Zhang, Liqin Tang, Yan Fang, Hongxiao Chen, Lei Zhang, Aizong Shen

Erratum issuedAbstract read
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In one paragraph

Article in Pharmacological reports : PR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhaolin Chen *Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, 230001, P.R. China.
Xi Cheng *Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, 230001, P.R. China.
Liwen ZhangDepartment of Data & Analytics, WuXi Diagnostics Limited Corporation, Shanghai, 200131, People's Republic of China.
Liqin TangDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, 230001, P.R. China.
Yan FangDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, 230001, P.R. China.
Hongxiao ChenDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, 230001, P.R. China.
Lei ZhangDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, 230001, P.R. China. zhanglei6@ustc.edu.cn.ORCID http://orcid.org/0000-0002-7996-0674
Aizong ShenDepartment of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, 230001, P.R. China. shenaizong@ustc.edu.cn.ORCID http://orcid.org/0000-0001-9009-6410
University of Science and Technology of China · CN

Funding

Anhui Natural Science Fund Project 1908085QH363China Postdoctoral Science Foundation 2019M662207
6 · The paper itself

Abstract

backgroundThe strong inter-individual pharmacokinetic variability and the narrow therapeutic window of tacrolimus (TAC) have hampered the clinical application. Gene polymorphisms play an important role in TAC pharmacokinetics. Here, we investigate the influence of genotypes of IL-10, CYP3A5, CYP2C8, and ABCB1 on dose-adjusted trough blood concentrations (the C

methodsGenetic polymorphisms of IL-10, CYP3A5, CYP2C8, and ABCB1 in 188 renal transplant recipients were determined using Kompetitive Allele Specific PCR (KASP). Statistical analysis was applied to examine the effect of genetic variation on the TAC C

resultsRecipients carrying the IL-10 -819C > T TT genotype showed a significantly higher TAC C

conclusionsGenetic polymorphisms of IL-10 -819C > T and CYP3A5 6986A > G influence the TAC C

Indexed as

AdultCytochrome P-450 CYP3ADose-Response Relationship, DrugFemaleGene Expression RegulationGenotypeHumansImmunosuppressive AgentsInterleukin-10Kidney TransplantationMalePolymorphism, Single NucleotideTacrolimusTransplant RecipientsYoung AdultCYP3A5 protein, humanCytochrome P-450 CYP3AImmunosuppressive AgentsInterleukin-10TacrolimusCYP3A5IL-10Kidney transplantationPolymorphismTacrolimus

Identifiers

PMID34089513
OpenAlexW3164992251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.