Evidence map›Paper›PMID 34089501›Full record

ArticleUpdates in surgery2021

The Italian Consensus on minimally invasive simultaneous resections for synchronous liver metastasis and primary colorectal cancer: A Delphi methodology.

Aldo Rocca, Federica Cipriani, Giulio Belli, Stefano Berti, Ugo Boggi, Vincenzo Bottino, Umberto Cillo, Matteo Cescon, Matteo Cimino, Francesco Corcione and 37 more

Open access · greenAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Updates in surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Evaluation of albumin-binding PD-L1-targeted VHH for PET imaging in colorectal cancer.American journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. RoboticHeliyon · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Evaluation of the ACS-NSQIP Surgical Risk Calculator in Patients with Hepatic Metastases from Colorectal Cancer Undergoing Liver Resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors at 20 institutions in 1 country.

Aldo Rocca *Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy. aldo.rocca@unimol.it.ORCID http://orcid.org/0000-0003-3807-3865
Federica Cipriani *Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giulio BelliDepartment of General and HPB Surgery, Loreto Nuovo Hospital, Naples, Italy.
Stefano BertiDepartment of Surgery, Hospital S Andrea La Spezia, La Spezia, Italy.
Ugo BoggiDivision of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy.
Vincenzo BottinoDepartment of Obesity and Metabolic Surgery, Ospedale Evangelico Betania, Naples, Italy.
Umberto CilloHepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery, Oncology and Gastroenterology, Padova University Hospital, Padua, Italy.
Matteo CesconGeneral Surgery and Transplant Unit, IRCCS AOU Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Matteo CiminoDivision of Hepatobiliary and General Surgery, Department of Surgery, Humanitas Clinical and Research Center, IRCCS, Humanitas University, Rozzano, MI, Italy.
Francesco CorcioneDepartment of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.
Luciano De CarlisDivision of General Surgery and Abdominal Transplantation, ASST Grande Ospedale Metropolitano Niguarda, School of Medicine, University of Milano-Bicocca, Milan, Italy.
Maurizio DegiuliDepartment of Oncology, Digestive and Surgical Oncology, San Luigi University Hospital, University of Torino, Orbassano, Italy.
Paolo De PaolisGeneral Surgery Department, Ospedale Gradenigo, Turin, Italy.
Agostino Maria De RoseHepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
Domenico D'UgoGeneral Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University, Rome, Italy.
Fabrizio Di BenedettoHepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Ugo ElmoreVita-Salute San Raffaele University, Milan, Italy.
Giorgio ErcolaniGeneral and Oncologic Surgery, Morgagni-Pierantoni Hospital, Forli, Italy.
Giuseppe M EttorreDepartment of General Surgery and Transplantation, San Camillo-Forlanini General Hospital, Rome, Italy.
Alessandro FerreroDepartment of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy.
Marco FilauroGeneral and Hepatobiliopancreatic Surgery Unit, Department of Abdominal Surgery, E.O. Galliera Hospital, Genoa, Italy.
Felice GiulianteHepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
Salvatore GruttadauriaAbdominal Surgery and Organ Transplantation Unit, Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, ISMETT, Palermo, Italy.
Alfredo GuglielmiUnit of HPB Surgery, Department of Surgery, GB Rossi University Hospital, Verona, Italy.
Francesco IzzoDivisions of Hepatobiliary Surgery, Istituto Nazionale Dei Tumori IRCCS "Fondazione G. Pascale", Naples, Italy.
Elio JovineDepartment of Surgery, AOU Sant'Orsola Malpighi, IRCCS, Bologna, Italy.
Andrea LaurenziGeneral and Oncologic Surgery, Morgagni-Pierantoni Hospital, Forli, Italy.
Francesco MarchegianiHepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery, Oncology and Gastroenterology, Padova University Hospital, Padua, Italy.
Pierluigi MariniThe Department of General and Emergency Surgery, San Camillo-Forlanini Regional Hospital, Rome, Italy.
Marco MassaniDepartment of Surgery, Regional Hospital of Treviso, Treviso, Italy.
Vincenzo MazzaferroDepartment of Gastrointestinal Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy.
Michela MinecciaDepartment of General Surgery and Transplantation, San Camillo-Forlanini General Hospital, Rome, Italy.
Francesco MinniDivision of Pancreatic Surgery, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Andrea MuratoreGeneral Surgery Unit, E. Agnelli Hospital, Pinerolo, TO, Italy.
Simone NicosiaDepartment of Surgery, AOU Sant'Orsola Malpighi, IRCCS, Bologna, Italy.
Riccardo PellicciGeneral Surgery Unit, Santa Corona Hospital, Pietra Ligure, SV, Italy.
Riccardo RosatiVita-Salute San Raffaele University, Milan, Italy.
Nadia RussolilloDepartment of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy.
Antonino SpinelliDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele, MI, Italy.
Gaya SpolveratoSurgery Unit, Department of Surgical Oncology and Gastroenterology Sciences (DiSCOG), University of Padua, Padua, Italy.
Guido TorzilliDivision of Hepatobiliary and General Surgery, Department of Surgery, Humanitas Clinical and Research Center, IRCCS, Humanitas University, Rozzano, MI, Italy.
Giovanni VennarecciLaparoscopic, Hepatic, and Liver Transplant Unit, AORN A. Cardarelli, Naples, Italy.
Luca ViganòDivision of Hepatobiliary and General Surgery, Department of Surgery, Humanitas Clinical and Research Center, IRCCS, Humanitas University, Rozzano, MI, Italy.
Leonardo VincentiMedical Oncology Unit, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Bari, Italy.
Paolo Delrio *Colorectal Surgical Oncology-Abdominal Oncology Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Giovanni Pascale' IRCCS, 80131, Naples, Italy.
Fulvio Calise *Center for Hepatobiliary and Pancreatic Surgery, Pineta Grande Hospital, Castel Volturno, Italy.
Luca Aldrighetti *Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Humanitas University · ITVita-Salute San Raffaele University · ITCarlo Forlanini Hospital · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversity of Padua · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITOspedale G.B. Morgagni - L.Pierantoni · ITUniversità Cattolica del Sacro Cuore · ITAgostino Gemelli University Polyclinic · ITCa' Foncello Hospital · ITEnte Ospedaliero Ospedali Galliera · ITFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITIstituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione · ITIstituto Tumori Bari · ITOspedale Antonio Cardarelli · ITOspedale Civile Edoardo Agnelli · ITOspedale Humanitas Gradenigo · ITOspedale Santa Corona · ITOspedale Santa Maria di Loreto Nuovo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At the time of diagnosis synchronous colorectal cancer, liver metastases (SCRLM) account for 15-25% of patients. If primary tumour and synchronous liver metastases are resectable, good results may be achieved performing surgical treatment incorporated into the chemotherapy regimen. So far, the possibility of simultaneous minimally invasive (MI) surgery for SCRLM has not been extensively investigated. The Italian surgical community has captured the need and undertaken the effort to establish a National Consensus on this topic. Four main areas of interest have been analysed: patients' selection, procedures, techniques, and implementations. To establish consensus, an adapted Delphi method was used through as many reiterative rounds were needed. Systematic literature reviews were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses instructions. The Consensus took place between February 2019 and July 2020. Twenty-six Italian centres participated. Eighteen clinically relevant items were identified. After a total of three Delphi rounds, 30-tree recommendations reached expert consensus establishing the herein presented guidelines. The Italian Consensus on MI surgery for SCRLM indicates possible pathways to optimise the treatment for these patients as consensus papers express a trend that is likely to become shortly a standard procedure for clinical pictures still on debate. As matter of fact, no RCT or relevant case series on simultaneous treatment of SCRLM are available in the literature to suggest guidelines. It remains to be investigated whether the MI technique for the simultaneous treatment of SCRLM maintain the already documented benefit of the two separate surgeries.

Indexed as

Colorectal NeoplasmsLiver NeoplasmsHepatectomyHumansItalyColorectal cancerConsensusMinimally invasive surgerySynchronous colorectal liver metastases

Identifiers

PMID34089501
OpenAlexW3165560115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.