Evidence map›Paper›PMID 34089273›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging.

Yiqiang Zhang, Wen-Jun Shen, Shuo Qiu, Pinglin Yang, Garrett Dempsey, Lei Zhao, Qin Zhou, Xiao Hao, Dachuan Dong, Andreas Stahl and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yiqiang ZhangDivision of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Wen-Jun ShenDivision of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Shuo QiuDivision of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Pinglin YangDivision of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Garrett DempseyDepartment of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA, USA.
Lei ZhaoVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Qin ZhouVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Xiao HaoDivision of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Dachuan DongDivision of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Andreas StahlDepartment of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA, USA.
Fredric B KraemerDivision of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2468-7807
Lawrence L LeungVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
John MorserVeterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.ORCID 0000-0003-3376-8692

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Cellular mechanobiology and engineering of active brown adipose tissueR01DK118940 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI KUMAR, SANJAY, STAHL, ANDREAS · 2019 to 2022
$2.3M
Role of CoQ in regulating thermogenesisR01DK126830 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI STAHL, ANDREAS · 2021 to 2024
$1.8M
BLRD VA I01 BX000398BLRD VA I01 BX001959NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK118940NIDDK NIH HHS R01 DK126830
6 · The paper itself

Abstract

Apart from its role in inflammation and immunity, chemerin is also involved in white adipocyte biology. To study the role of chemerin in adipocyte metabolism, we examined the function of chemerin in brown adipose tissue. Brown and white adipocyte precursors were differentiated into adipocytes in the presence of Chemerin siRNA. Chemerin-deficient (Chem

Indexed as

Diet, High-FatEnergy MetabolismInsulin ResistanceAdipose Tissue, BrownAgingAnimalsChemokinesFemaleHyperinsulinismIntercellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLOxygen ConsumptionThermogenesischemerin protein, mouseChemokinesIntercellular Signaling Peptides and Proteinsadipocytesadipokineschemerinenergy balance

Identifiers

PMID34089273
PMCPMC8958903

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.