Evidence map›Paper›PMID 34089205›Full record

ArticleJournal of cutaneous pathology2021

Secondary skin involvement in classic Hodgkin lymphoma: Results of an international collaborative cutaneous lymphoma working group study of 25 patients.

Alejandro A Gru, Carlos E Bacchi, Melissa Pulitzer, Govind Bhagat, Werner Kempf, Alistair Robson, Jose A Plaza, Laura Pincus, Shyam Raghavan, Mina Xu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cutaneous pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Secondary lymphomas of the skin.Dermatology reports · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alejandro A GruDepartment of Pathology, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-2573-8074
Carlos E BacchiLab Bacchi, Botucatu, SP, Brazil.
Melissa PulitzerDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0002-0606-9186
Govind BhagatDepartment of Pathology, Columbia University, New York, New York, USA.
Werner KempfKempf und Pfaltz Histologische Diagnostik, Zurich, Switzerland.
Alistair RobsonInstitute of Oncology, Lisbon, Portugal and LDPath London, London, UK.
Jose A PlazaDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Laura PincusDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Shyam RaghavanDepartment of Pathology, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0002-3816-1542
Mina XuDepartment of Pathology, Yale University, New Haven, Connecticut, USA.
Tiago Vencato da SilvaLab Bacchi, Botucatu, SP, Brazil.
Andrea L SalavaggioneDepartment of Pathology, University of Virginia, Charlottesville, Virginia, USA.
Antonio SubtilDepartment of Pathology, Royal Jubilee Hospital, Victoria, British Columbia, Canada.ORCID https://orcid.org/0000-0002-6401-1900
Maxime BattistellaPathology Department, Université de Paris, Hôpital Saint-Louis, Paris, France.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundCutaneous involvement by classic Hodgkin lymphoma (CHL) is an extraordinarily rare phenomenon in the current era. To date, no single large case series of cutaneous involvement by Hodgkin lymphoma has ever been reported in the literature.

methodsA comprehensive search for cases designated "skin" and "Hodgkin" was performed at different institutions between 1990 and 2020. Twenty-five cases were identified, and each case was independently reviewed by at least three board-certified dermatopathologists and/or hematopathologists.

resultsAll cases represented examples of systemic CHL with secondary skin dissemination. A single lesion, usually a tumor, nodule or infiltrative plaque was observed in 56% of cases and multiple lesions were present in 28% of cases. Most patients (86%-12/14) had a diagnosis of stage IV disease at first diagnosis. The interval between the clinical (first) diagnosis of HL and the development of skin lesions ranged between 6 and 108 months (average 33.75 months). Comprehensive histopathologic evaluation of these cases (at the initial diagnosis) revealed a diagnosis of classic HL not otherwise specified (NOS) in 60% of cases (15/25), nodular sclerosis type in 24% (6/25), mixed cellularity in 12% (3/25), and lymphocyte depleted in 4% (1/25).

conclusionsWe provide documentation of a large series of CHL with secondary skin involvement in association with CHL with additional clinical, morphologic, and immunophenotypic features.

Indexed as

AdultAgedAged, 80 and overFemaleHodgkin DiseaseHumansMaleMiddle AgedRetrospective StudiesSkin Neoplasmscutaneous lymphomaHodgkin lymphomaskin involvement

Identifiers

PMID34089205
PMCPMC9555338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.