Evidence map›Paper›PMID 34089175›Full record

ArticleGeroScience2021

Age and sex modify cellular proliferation responses to oxidative stress and glucocorticoid challenges in baboon cells.

Daniel A Adekunbi, Cun Li, Peter W Nathanielsz, Adam B Salmon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Daniel A AdekunbiTexas Pregnancy and Life-Course Health Research Center, Department of Animal Science, University of Wyoming, Laramie, WY, USA.ORCID 0000-0001-5456-3392
Cun LiTexas Pregnancy and Life-Course Health Research Center, Department of Animal Science, University of Wyoming, Laramie, WY, USA.
Peter W NathanielszTexas Pregnancy and Life-Course Health Research Center, Department of Animal Science, University of Wyoming, Laramie, WY, USA.ORCID 0000-0001-8410-6280
Adam B SalmonBarshop Institute for Longevity and Aging Studies and Department of Molecular Medicine, The University of Texas Health Science Center At San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229, USA. salmona@uthscsa.edu.
University of Wyoming · USThe University of Texas Health Science Center at San Antonio · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Womb to Tomb: Developmental Programming and Aging Interactions in PrimatesU19AG057758 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CLARKE, GEOFFREY DAVID, COX, LAURA A · 2018 to 2024
$13.2M
The role of mTOR inhibition on longevity and healthy aging in a non-human primateR01AG050797 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SALMON, ADAM · 2015 to 2019
$2.7M
Primary fibroblast resiliency as a predictor of health and lifespan in miceR01AG057431 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SALMON, ADAM · 2017 to 2021
$1.6M
NIA NIH HHS P30 AG013319NIA NIH HHS R01 AG050797NIA NIH HHS R01 AG057431NIA NIH HHS U19 AG057758NIH HHS P51 OD011133
6 · The paper itself

Abstract

Aging is associated with progressive loss of cellular homeostasis resulting from intrinsic and extrinsic challenges. Lack of a carefully designed, well-characterized, precise, translational experimental model is a major limitation to understanding the cellular perturbations that characterize aging. Here, we tested the feasibility of primary fibroblasts isolated from nonhuman primates (baboons) as a model of cellular resilience in response to homeostatic challenge. Using a real-time live-cell imaging system, we precisely defined a protocol for testing effects of prooxidant compounds (e.g., hydrogen peroxide (H

Indexed as

GlucocorticoidsHydrogen PeroxideAnimalsCell ProliferationFemaleMaleOxidative StressPapioGlucocorticoidsHydrogen PeroxideAgingBaboonCell proliferationFibroblastOxidative stressResilience

Identifiers

PMID34089175
PMCPMC8492861
OpenAlexW3165837985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.