ArticleIntensive care medicine2021
Predictors of death and new disability after critical illness: a multicentre prospective cohort study.
Article in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The PREDICT Study- a Registry in Critically Ill Patients to Determine Predictors of Disability Free Survival
Assessment of Clinical Practice of Mechanical Ventilation After COVID-19 Pan-demic Among 57 Countries: A Systematic Analysis for the Global BurdEn of Me-chanIcal VeNtilatIon (GEMINI Study) 2022, From VENTILAGROUP.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Persistent Features of Laryngeal Injury Following Endotracheal Intubation: A Systematic Review.Dysphagia · 2023Pooled it
- Health-related quality of life correlates with patient-reported and proxy-reported disability in critical illness survivors: a secondary analysis of the ERIC trial.Critical care (London, England) · 2025Trial
- Association between preoperative frailty and 30-day functional disability after surgery: a prospective cohort study using the Edmonton Frail Scale.BMC anesthesiology · 2026Article
- Muscle Dysfunction and Physical Recovery After Critical Illness.Journal of intensive care medicine · 2026Review
- Psychometric comparison and score conversion between World Health Organization Disability Assessment Schedule 2.0 and activities of daily living scales in community-dwelling older adults.European geriatric medicine · 2025Observational
- Rinaldo Bellomo and the evolution of critical care survivorship.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Risk prediction models for post-intensive care syndrome of ICU discharged patients: A systematic review.International journal of nursing sciences · 2025Review
- Serum acylcarnitines profile at ICU discharge to predict mid-term muscle outcomes: an exploratory study.Frontiers in medicine · 2025Article
- Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors: A Pilot Study.CHEST critical care · 2024Article
- Development and validation of a machine learning-based model for post-sepsis frailty.ERJ open research · 2024Article
- Thrombolysis before venoarterial ECMO for high-risk pulmonary embolism: a retrospective cohort study.Intensive care medicine · 2024Article
- Integrating machine learning with bioinformatics for predicting idiopathic pulmonary fibrosis prognosis: developing an individualized clinical prediction tool.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- To mobilise or not to mobilise: is that the right question?Intensive care medicine · 2023Article
- Article
- Preoperative systemic immune-inflammation index may predict prolonged mechanical ventilation in patients with spontaneous basal ganglia intracerebral hemorrhage undergoing surgical operation.Frontiers in neurology · 2023Article
- Development and validation of a prediction model for persistent functional impairment among older ICU survivors.Journal of the American Geriatrics Society · 2023Article
- Article
- Comparison of 6-month outcomes of sepsis versus non-sepsis critically ill patients receiving mechanical ventilation.Critical care (London, England) · 2022Article
- Development and validation of early prediction models for new-onset functional impairment at hospital discharge of ICU admission.Intensive care medicine · 2022Article
- Comparison of 6-Month Outcomes of Survivors of COVID-19 versus Non-COVID-19 Critical Illness.American journal of respiratory and critical care medicine · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
purposeThis study aimed to determine the prevalence and predictors of death or new disability following critical illness.
methodsProspective, multicentre cohort study conducted in six metropolitan intensive care units (ICU). Participants were adults admitted to the ICU who received more than 24 h of mechanical ventilation. The primary outcome was death or new disability at 6 months, with new disability defined by a 10% increase in the WHODAS 2.0.
resultsOf 628 patients with the primary outcome available (median age of 62 [49-71] years, 379 [61.0%] had a medical admission and 370 (58.9%) died or developed new disability by 6 months. Independent predictors of death or new disability included age [OR 1.02 (1.01-1.03), P = 0.001], higher severity of illness (APACHE III) [OR 1.02 (1.01-1.03), P < 0.001] and admission diagnosis. Compared to patients with a surgical admission diagnosis, patients with a cardiac arrest [OR (95% CI) 4.06 (1.89-8.68), P < 0.001], sepsis [OR (95% CI) 2.43 (1.32-4.47), P = 0.004], or trauma [OR (95% CI) 6.24 (3.07-12.71), P < 0.001] diagnosis had higher odds of death or new disability, while patients with a lung transplant [OR (95% CI) 0.21 (0.07-0.58), P = 0.003] diagnosis had lower odds. A model including these three variables had good calibration (Brier score 0.20) and acceptable discriminative power with an area under the receiver operating characteristic curve of 0.76 (95% CI 0.72-0.80).
conclusionLess than half of all patients mechanically ventilated for more than 24 h were alive and free of new disability at 6 months after admission to ICU. A model including age, illness severity and admission diagnosis has acceptable discriminative ability to predict death or new disability at 6 months.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.