ArticleNature protocols2021
Raman spectroscopy for real-time and in situ monitoring of mechanochemical milling reactions.
Article in Nature protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Rice straw sample preparation protocol for cell wall major constituent analysis via Raman spectroscopy.STAR protocols · 2026Article
- Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations.Angewandte Chemie (International ed. in English) · 2026Review
- Deciphering Ball Milling Mechanochemistry via Molecular Simulations of Collision-Driven and Liquid-Assisted Reactivity.Angewandte Chemie (International ed. in English) · 2025Article
- Mechanochemistry for Metal-Organic Frameworks and Covalent-Organic Frameworks (MOFs, COFs): Methods, Materials, and Mechanisms.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- How to Track Mechanochemical Reactions in Resonant Acoustic Mixers by in Situ Raman Spectroscopy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Article
- Mechanochemistry: Fundamental Principles and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Kinetics of the mechanochemical transformations in the "glycine - oxalic acid dihydrate" system revisited: The role of water.Frontiers in chemistry · 2025Article
- Deep autoencoder as an interpretable tool for Raman spectroscopy investigation of chemical and extracellular vesicle mixtures.Biomedical optics express · 2024Article
- One Step In Situ Co-Crystallization of Dapsone and Polyethylene Glycols during Fluidized Bed Granulation.Pharmaceutics · 2023Article
- Polymorphism of Carbamazepine Pharmaceutical Cocrystal: Structural Analysis and Solubility Performance.Pharmaceutics · 2023Article
- Synthesis andACS omega · 2023Article
- The Transformation of Inorganic to Organic Carbonates: Chasing for Reaction Pathways in Mechanochemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Towards time resolved characterization of electrochemical reactions: electrochemically-induced Raman spectroscopy.Chemical science · 2022Article
- Time-Resolved In Situ Monitoring of Mechanochemical Reactions.Angewandte Chemie (International ed. in English) · 2022Review
- Sustainable Production of Reduced Phosphorus Compounds: Mechanochemical Hydride Phosphorylation Using Condensed Phosphates as a Route to Phosphite.ACS central science · 2022Article
- Mix and wait - a relaxed way for synthesizing ZIF-8.RSC advances · 2022Article
- Mechanistic Insights on the Mechanosynthesis of Phenytoin, a WHO Essential Medicine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Multi-faceted reactivity ofBeilstein journal of organic chemistry · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solid-state milling has emerged as an alternative, sustainable approach for preparing virtually all classes of compounds and materials. In situ reaction monitoring is essential to understanding the kinetics and mechanisms of these reactions, but it has proved difficult to use standard analytical techniques to analyze the contents of the closed, rapidly moving reaction chamber (jar). Monitoring by Raman spectroscopy is an attractive choice, because it allows uninterrupted data collection from the outside of a translucent milling jar. It complements the already established in situ monitoring based on powder X-ray diffraction, which has limited accessibility to the wider research community, because it requires a synchrotron X-ray source. The Raman spectroscopy monitoring setup used in this protocol consists of an affordable, small portable spectrometer, a laser source and a Raman probe. Translucent reaction jars, most commonly made from a plastic material, enable interaction of the laser beam with the solid sample residing inside the closed reaction jar and collection of Raman-scattered photons while the ball mill is in operation. Acquired Raman spectra are analyzed using commercial or open-source software for data analysis (e.g., MATLAB, Octave, Python, R). Plotting the Raman spectra versus time enables qualitative analysis of reaction paths. This is demonstrated for an example reaction: the formation in the solid state of a cocrystal between nicotinamide and salicylic acid. A more rigorous data analysis can be achieved using multivariate analysis.
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