ArticleNature protocols2021
Selected ion flow tube mass spectrometry for targeted analysis of volatile organic compounds in human breath.
Article in Nature protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Advanced strategy for cancer detection based on volatile organic compounds in breath.Journal of nanobiotechnology · 2025Pooled it
- Volatile organic compounds in exhaled human breath for the diagnosis of malignant pleural mesothelioma: a meta-analysis.Frontiers in oncology · 2025Pooled it
- Exploring Components, Sensors, and Techniques for Cancer Detection via eNose Technology: A Systematic Review.Sensors (Basel, Switzerland) · 2024Pooled it
- Evaluating the VOCORDER device for early disease detection through breath analysis: study protocol for a two-phase clinical study.BMJ open · 2026Article
- Real-Time Breath Diagnostics: Linking Molecular Pathways, Measurement Technologies, and Clinical Translation.International journal of molecular sciences · 2026Review
- Methanol-driven esterification of volatile short-chain fatty acids in thermal desorption-based analysis.Communications chemistry · 2026Article
- Microfluidic approaches for liquid biopsy in glioblastoma: Insights into diagnostic and follow-up strategies.Bioengineering & translational medicine · 2026Review
- Unlocking the Translational Potential of Nanophotonic Biosensors: Perspectives on Application-Guided Design.ACS photonics · 2025Review
- Non-invasive breath testing to detect colorectal cancer: protocol for a multicentre, case-control development and validation study (COBRA2 study).BMC cancer · 2025Article
- Detection of Volatile Organic Compounds as an emerging strategy for Parkinson's disease diagnosis and monitoring.NPJ Parkinson's disease · 2025Article
- Volatilomic response to targeted cancer therapy in vitro.Scientific reports · 2025Article
- Harnessing Surface-Enhanced Raman Spectroscopy for Breath-Based Diagnostics.Analytical chemistry · 2025Article
- Article
- Surface Enhanced Raman Scattering for Biomolecular Sensing in Human Healthcare Monitoring.ACS nano · 2025Review
- Advancing frontiers in skin offensive odor management: from innovative diagnostics to cutting-edge treatments and emerging technologies.Archives of dermatological research · 2025Review
- High and low pathogenicity avian influenza virus discrimination and prediction based on volatile organic compounds signature by SIFT-MS: a proof-of-concept study.Scientific reports · 2024Article
- Noninvasive Diabetes Detection through Human Breath Using TinyML-Powered E-Nose.Sensors (Basel, Switzerland) · 2024Article
- Combining Thermal Desorption with Selected Ion Flow Tube Mass Spectrometry for Analyses of Breath Volatile Organic Compounds.Analytical chemistry · 2024Article
- Volatilomes of human infection.Analytical and bioanalytical chemistry · 2024Review
- Pioneering noninvasive colorectal cancer detection with an AI-enhanced breath volatilomics platform.Theranostics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The analysis of volatile organic compounds (VOCs) within breath for noninvasive disease detection and monitoring is an emergent research field that has the potential to reshape current clinical practice. However, adoption of breath testing has been limited by a lack of standardization. This protocol provides a comprehensive workflow for online and offline breath analysis using selected ion flow tube mass spectrometry (SIFT-MS). Following the suggested protocol, 50 human breath samples can be analyzed and interpreted in <3 h. Key advantages of SIFT-MS are exploited, including the acquisition of real-time results and direct compound quantification without need for calibration curves. The protocol includes details of methods developed for targeted analysis of disease-specific VOCs, specifically short-chain fatty acids, aldehydes, phenols, alcohols and alkanes. A procedure to make custom breath collection bags is also described. This standardized protocol for VOC analysis using SIFT-MS is intended to provide a basis for wider application and the use of breath analysis in clinical studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.