ReviewModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2021
Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine.
Review in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- FIGO staging for gestational trophoblastic neoplasia: 2026.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Guideline
- Emerging roles of mJournal of assisted reproduction and genetics · 2026Review
- Insights into Reproductive Immunology and Placental Pathology, 2nd Edition.International journal of molecular sciences · 2026Article
- A rare case of fallopian tubal choriocarcinoma rupture coexistent with intrauterine pregnancy.BMC pregnancy and childbirth · 2026Article
- Primary Uterine Nongestational Placental Site Trophoblastic Tumor as a Distinct Entity: A Report of 5 Cases.The American journal of surgical pathology · 2026Article
- Case Report: Recurrent pelvic gestational choriocarcinoma arising from an occult complete mole unmasked by short tandem repeat genotyping.Frontiers in oncology · 2026Article
- Post-term gestational choriocarcinoma presenting with hemorrhagic brain and bilateral renal metastases: a rare case report.Annals of medicine and surgery (2012) · 2025Article
- Precision Diagnosis and Individualized Therapy of Non-Gestational Choriocarcinoma Invading the Corpus Uteri and Cervix: A Case Report and Literature Review.Cancer reports (Hoboken, N.J.) · 2025Review
- STR genotyping diagnosis of hydatidiform moles: an assessment of 2871 consecutive products of conceptions.Virchows Archiv : an international journal of pathology · 2025Article
- Reappraisal and refined diagnosis of ultrasonography and histological findings for hydatidiform moles: a multicentre retrospective study of 821 patients.Journal of clinical pathology · 2025Article
- Diagnostic pitfall in primary cervical gestational choriocarcinoma: a case report.Frontiers in oncology · 2025Article
- Ethnic disparities in complete and partial molar pregnancy incidence: a retrospective analysis of arab and jewish women in single medical center.BMC public health · 2024Article
- Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles.Virchows Archiv : an international journal of pathology · 2024Review
- Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cure.Frontiers in oncology · 2022Article
- When a vesicular placenta meets a live fetus: case report of twin pregnancy with a partial hydatidiform mole.BMC pregnancy and childbirth · 2021Article
- The Contribution of QF-PCR and Pathology Studies in the Diagnosis of Diandric Triploidy/Partial Mole.Diagnostics (Basel, Switzerland) · 2021Article
- Outcomes in gestational and non-gestational choriocarcinoma: A retrospective cohort study with nomograms and web tools.Women's health (London, England)Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Investigations in recent decades have exploited tissue DNA genotyping as a powerful ancillary tool for the precision diagnosis and subclassification of gestational trophoblastic disease. As lesions of gestational origin, the inherited paternal genome, with or without copy number alterations, is the fundamental molecular basis for the diagnostic applications of DNA genotyping. Genotyping is now considered the gold standard in the confirmation and subtyping of sporadic hydatidiform moles. Although a precise diagnosis of partial mole requires DNA genotyping, prognostic stratification according to distinct genetic zygosity in complete moles has recently gained significant clinical relevance for patient care. Beyond hydatidiform moles, DNA genotyping has fundamental applications in the diagnosis or prognostic assessment of gestational trophoblastic tumors, in particular gestational choriocarcinoma. DNA genotyping provides a decisive tool in the separation of gestational trophoblastic neoplasia from non-gestational counterparts/mimics of either germ cell or somatic origin. The FIGO/WHO prognostic scoring scheme requires ascertaining the precise index gestational event and the time interval between the tumor and index gestation, where DNA genotyping can provide highly relevant information. With rapid acquisition of molecular diagnostic capabilities in the clinical practice, DNA genotyping has become closely integrated into the routine diagnostic workup of various forms of gestational trophoblastic disease.
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