Evidence map›Paper›PMID 34088984›Full record

ArticlePediatric research2022

Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children's Study.

Kazutoshi Cho, Sumitaka Kobayashi, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Yasuaki Saijo, Yoshiya Ito, Kazuo Sengoku, Tsuyoshi Baba, Hisanori Minakami and 3 more

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In one paragraph

Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. An Association between Maternal Occupations and Low Birth Weight Infants in Japan from 1995 to 2015.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kazutoshi ChoMaternity and Perinatal Care Center, Hokkaido University Hospital, Sapporo, Japan.
Sumitaka KobayashiCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan. sukobayashi@cehs.hokudai.ac.jp.
Atsuko ArakiCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
Chihiro MiyashitaCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
Sachiko ItohCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
Yasuaki SaijoDepartment of Social Medicine, Asahikawa Medical University, Asahikawa, Japan.
Yoshiya ItoFaculty of Nursing, Japanese Red Cross Hokkaido College of Nursing, Kitami, Japan.
Kazuo SengokuDepartment of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
Tsuyoshi BabaDepartment of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University, Sapporo, Japan.
Hisanori MinakamiMaternity and Perinatal Care Center, Hokkaido University Hospital, Sapporo, Japan.
Yuichi NakamuraMaternity and Perinatal Care Center, Hokkaido University Hospital, Sapporo, Japan.
Reiko KishiCenter for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
Japan Environment and Children’s Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsJapanese studies on the association between maternal alcohol consumption and fetal growth are few. This study assessed the effect of maternal alcohol consumption on fetal growth.

methodsThis prospective birth cohort included 95,761 participants enrolled between January 2011 and March 2014 in the Japan Environment and Children's Study. Adjusted multiple linear and logistic regression models were used to assess the association between prenatal alcohol consumption and infant birth size.

resultsConsumption of a weekly dose of alcohol in the second/third trimester showed a significant negative correlation with standard deviation (SD; Z) scores for body weight, body length, and head circumference at birth, respectively. Consumption of a weekly dose of alcohol during the second/third trimester had a significant positive correlation with incidences of Z-score ≤ -1.5 for birth head circumference. Associations between alcohol consumption in the second/third trimester and Z-score ≤ -1.5 for birth weight or birth length were not significant. Maternal alcohol consumption in the second/third trimester above 5, 20, and 100 g/week affected body weight, body length, and head circumference at birth, respectively.

conclusionLow-to-moderate alcohol consumption during pregnancy might affect fetal growth. Public health policies for pregnant women are needed to stop alcohol consumption during pregnancy. IMPACT: This study examined the association between maternal alcohol consumption and fetal growth restriction in 95,761 pregnant Japanese women using the prospective birth cohort. Maternal alcohol consumption in the second/third trimester more than 5, 20, and 100 g/week might affect fetal growth in body weight, body length, and head circumference, respectively. The findings are relevant and important for educating pregnant women on the adverse health effects that prenatal alcohol consumptions have on infants.

Indexed as

Fetal Growth RetardationPrenatal Exposure Delayed EffectsBirth WeightChildEthanolFemaleFetal DevelopmentHumansInfantInfant, NewbornJapanMaternal ExposurePregnancyProspective StudiesEthanol

Identifiers

PMID34088984

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.