Evidence map›Paper›PMID 34088934›Full record

ArticleScientific reports2021

In vitro expansion of fetal liver hematopoietic stem cells.

Rashmi Bhardwaj, Lalit Kumar, Deepika Chhabra, N K Mehra, Atul Sharma, Sujata Mohanty, Vinod Kochupillai

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rashmi BhardwajInstitute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Lalit KumarInstitute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Deepika ChhabraSri Sri Institute For Advanced Research (SSIAR), Ved Vignan Maha Vidhya Peeth (VVMVP), F003 Soudhamini Apartment, 21st Kanakpura Road, Art of Living International Center, Udaipura, Bengaluru, 560082, India. chhabra.deepika@gmail.com.
N K MehraInstitute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Atul SharmaInstitute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Sujata MohantyInstitute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Vinod KochupillaiSri Sri Institute For Advanced Research (SSIAR), Ved Vignan Maha Vidhya Peeth (VVMVP), F003 Soudhamini Apartment, 21st Kanakpura Road, Art of Living International Center, Udaipura, Bengaluru, 560082, India.
All India Institute of Medical Sciences · INAll India Institute of Medical Sciences Raipur · INAll India Institute of Medical Sciences Bhopal · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fetal liver hematopoietic stem and progenitor cells (HSPCs) have been considered appropriate for the management of aplastic anemia owing to their proliferative potential. Bone marrow recovery was possible in some cases; the engraftment potential of these cells, however was unsatisfactory, possibly due to the availability of a smaller number of these cells from a single fetus. The present study explores how we can expand fetal liver hematopoietic stem cells under in vitro conditions. We isolated mononuclear cells from fetal liver and hematopoietic stem cells were identified and analyzed by cell surface marker CD34. CD34

Indexed as

Cell Culture TechniquesAnimalsAntigens, CD34Cell SeparationCell SurvivalCytokinesFemaleHematopoietic Stem CellsIn Vitro TechniquesKineticsLeukocytes, MononuclearLiverMagneticsMaleMiceStem CellsAntigens, CD34Cytokines

Identifiers

PMID34088934
PMCPMC8178329
OpenAlexW3127431517

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.