Evidence map›Paper›PMID 34088927›Full record

ArticleScientific reports2021

Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma.

Jasper C Lee, Demitra M Yotis, Ji Yun Lee, Marie A Sarabusky, Bradly Shrum, Audrey Champagne, Ola Z Ismail, Elena Tutunea-Fatan, Hon S Leong, Lakshman Gunaratnam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jasper C Lee *Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Demitra M Yotis *Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Ji Yun LeeDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Marie A SarabuskyDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Bradly ShrumMatthew Mailing Centre for Translational Transplant Studies, Lawson Health Research Institute, London, ON, Canada.
Audrey ChampagneCentre de recherche du CHU de Québec-Université Laval, CHU de Québec-Université Laval, Quebec City, QC, Canada.
Ola Z IsmailDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Elena Tutunea-FatanMatthew Mailing Centre for Translational Transplant Studies, Lawson Health Research Institute, London, ON, Canada.
Hon S LeongSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Lakshman GunaratnamDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Lakshman.Gunaratnam@lhsc.on.ca.ORCID 0000-0002-8845-1126
Western University · CALawson Health Research Institute · CASunnybrook Health Science Centre · CAUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis is present in approximately 30% of patients diagnosed with renal cell carcinoma (RCC) and is associated with a 5-year survival rate of < 15%. Kidney injury molecule 1 (KIM-1), encoded by the HAVCR1 gene, is a proximal tubule cell-surface glycoprotein and a biomarker for early detection of RCC, but its pathophysiological significance in RCC remains unclear. We generated human and murine RCC cell lines either expressing or lacking KIM-1, respectively, and compared their growth and metastatic properties using validated methods. Surprisingly, KIM-1 expression had no effect on cell proliferation or subcutaneous tumour growth in immune deficient (Rag1

Indexed as

AnimalsBiomarkers, TumorCarcinoma, Renal CellCell Line, TumorCell MembraneCell ProliferationFemaleGene Expression RegulationHepatitis A Virus Cellular Receptor 1Homeodomain ProteinsKidney NeoplasmsMiceMice, Inbred BALB CNeoplasm InvasivenessNeoplasm MetastasisPrognosisBiomarkers, TumorHavcr1 protein, mouseHepatitis A Virus Cellular Receptor 1Homeodomain ProteinsRAG-1 proteinRNA, MessengerRNA, Small Interfering

Identifiers

PMID34088927
PMCPMC8178330
OpenAlexW3165491920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.