ArticleAging2021
Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines.
Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 18 citations in OpenAlex.
- Aqueous Proteomic and Metabolomic Profiles in Low-Energy vs High-Energy Femtosecond Laser-Assisted Cataract Surgery.Investigative ophthalmology & visual science · 2025Trial
- Telomere variant sequences encode the genetic blueprint for allele-specific telomere length.Nature communications · 2026Article
- A machine learning approach to conglomerate multi-domain features of cardiac aging.European heart journal. Digital health · 2026Article
- Extreme Weather Events, Air Pollution, and Cardiovascular Health: Mechanisms and Challenges.Reviews in cardiovascular medicine · 2026Review
- Associations Between Right Ventricular Remodeling, Exercise and Circulating Metabolites in Volume and Pressure Overload States.JACC. Asia · 2026Article
- Uncoupling of energy metabolism and myocardial function in early left atrial dysfunction: a metabolomics study.Frontiers in cardiovascular medicine · 2026Article
- Metabolomic Pathways of Inflammation and Mitochondrial Dysfunction Are Related to Worsening Healthy Aging Index and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Associations between glycated haemoglobin and multi-modal imaging markers of early cardiac aging.GeroScience · 2025Observational
- Protein kinase C and endothelial dysfunction in select vascular diseases.Frontiers in cardiovascular medicine · 2025Review
- Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging.GeroScience · 2024Observational
- Dysregulation of Lipid Metabolism Serves as A Link Between Alzheimer's and Cardiovascular Disease, As Witnessed in A Cross-Sectional Study.Aging and disease · 2024Article
- Effects of short-term moderate intensity exercise on the serum metabolome in older adults: a pilot randomized controlled trial.Communications medicine · 2024Article
- Characteristics of pulmonary artery strain assessed by cardiovascular magnetic resonance imaging and associations with metabolomic pathways in human ageing.Frontiers in cardiovascular medicine · 2024Article
- Adverse cardiovascular and metabolic perturbations among older women: 'fat-craving' hearts.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.Aging cell · 2023Article
- High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform.Nature communications · 2023Article
- Metabolomics profile and 10-year atherosclerotic cardiovascular disease (ASCVD) risk score.Frontiers in cardiovascular medicine · 2023Article
- Plasma Quantitative Lipid Profiles: Identification of CarnitineC18:1-OH, CarnitineC18:2-OH and FFA (20:1) as Novel Biomarkers for Pre-warning and Prognosis in Acute Myocardial Infarction.Frontiers in cardiovascular medicine · 2022Article
- Cardiovascular Aging and Physical Activity: Insights From Metabolomics.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo demonstrate differences in cardiovascular structure and function between diabetic and non-diabetic older adults. To investigate associations between acyl-carnitines and cardiovascular function as indexed by imaging measurements.
methodsA community-based cohort of older adults without cardiovascular disease underwent current cardiovascular imaging and metabolomics acyl-carnitines profiling based on current and archived sera obtained fifteen years prior to examination.
resultsA total of 933 participants (women 56%, n=521) with a mean age 63±13 years were studied. Old diabetics compared to old non-diabetics had lower myocardial relaxation (0.8±0.2 vs 0.9±0.3, p=0.0039); lower left atrial conduit strain (12±4.3 vs 14±4.1, p=0.045), lower left atrial conduit strain rate (-1.2±0.4 vs -1.3±0.5, p=0.042) and lower ratio of left atrial conduit strain to left atrial booster strain (0.5±0.2 vs 0.7±0.3, p=0.0029). Higher levels of archived short chain acyl-carnitine were associated with present-day impairments in myocardial relaxation (C5:1; OR 1.03, p=0.011), worse left atrial conduit strain function (C5:1; OR 1.03, p=0.037). Increases in hydroxylated acyl-carnitines were associated with worse left atrial conduit strain [(C4-OH; OR 1.05, p=0.0017), (C16:2-OH; OR 1.18, p=0.037)]. Current, archived and changes in long chain acyl-carnitines were associated with cardiovascular functions [(C16; OR 1.02, p=0.002), (C20:3; OR 1.01, p=0.014), (C14:3; OR 1.12, p=0.033), (C18:1; OR 1.01, p=0.018), (C18:2; OR 1.01, p=0.028), (C20:4; OR 1.10, p=0.038)] (all p<0.05).
conclusionOlder diabetic adults had significant impairments in left ventricular myocardial relaxation and left atrial strain, compared to older non-diabetic adults. Short chain and long chain, di-carboxyl and hydroxylated acyl-carnitines were associated with these cardiovascular functional differences.
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Registered trials
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