Evidence map›Paper›PMID 34088845›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Critical role of the CD44

Yuka Nakajima, Kenji Chamoto, Takuma Oura, Tasuku Honjo

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Ad-SGE-DKK3 Gene Therapy Overcomes Resistance to Immune Checkpoint Blockade in Pleural Mesothelioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. T cell senescence induced by DNMT1 deletion mediates cardiac transplant tolerance via altered CDKN1A methylation.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  7. Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. p38γ and p38δ support CD4Frontiers in immunology · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Ageing, immune fitness and cancer.Nature reviews. Cancer · 2025
    Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuka NakajimaDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.ORCID 0000-0002-7357-2910
Kenji ChamotoDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
Takuma OuraDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.ORCID 0000-0002-8509-5410
Tasuku HonjoDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan honjo@mfour.med.kyoto-u.ac.jp.ORCID 0000-0003-2300-3928

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD8

Indexed as

AgingAnimalsCD8-Positive T-LymphocytesCell Line, TumorHyaluronan ReceptorsL-SelectinMiceMice, KnockoutNeoplasms, ExperimentalProgrammed Cell Death 1 ReceptorCd44 protein, mouseHyaluronan ReceptorsL-SelectinPdcd1 protein, mouseProgrammed Cell Death 1 Receptoragingimmunotherapyone-carbon metabolismPD-1T cell subset

Identifiers

PMID34088845
PMCPMC8201912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.