ArticleProceedings of the National Academy of Sciences of the United States of America2021
The relationship between birth timing, circuit wiring, and physiological response properties of cerebellar granule cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Spatial constraints and cell surface molecule depletion structure a randomly connected learning circuit.Current biology : CB · 2025Article
- Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma.bioRxiv : the preprint server for biology · 2024Article
- A cerebellar granule cell-climbing fiber computation to learn to track long time intervals.Neuron · 2024Article
- Postnatal zinc deficiency due to giardiasis disrupts hippocampal and cerebellar development.PLoS neglected tropical diseases · 2024Article
- The cerebellum directly modulates the substantia nigra dopaminergic activity.Nature neuroscience · 2024Article
- Mild Deficits in Fear Learning: Evidence from Humans and Mice with Cerebellar Cortical Degeneration.eNeuro · 2024Article
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Developmental timing-dependent organization of synaptic connections between mossy fibers and granule cells in the cerebellum.Communications biology · 2023Article
- Regulation of cerebellar network development by granule cells and their molecules.Frontiers in molecular neuroscience · 2023Review
- Cerebellum lineage allocation, morphogenesis and repair: impact of interplay amongst cells.Development (Cambridge, England) · 2022Review
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System.Frontiers in systems neuroscience · 2022Article
- Eavesdropping wires: Recording activity in axons using genetically encoded calcium indicators.Journal of neuroscience methods · 2021Review
- The Serendipity of Viral Trans-Neuronal Specificity: More Than Meets the Eye.Frontiers in cellular neuroscience · 2021Review
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Authors and funding
9 authors.
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Abstract
Cerebellar granule cells (GrCs) are usually regarded as a uniform cell type that collectively expands the coding space of the cerebellum by integrating diverse combinations of mossy fiber inputs. Accordingly, stable molecularly or physiologically defined GrC subtypes within a single cerebellar region have not been reported. The only known cellular property that distinguishes otherwise homogeneous GrCs is the correspondence between GrC birth timing and the depth of the molecular layer to which their axons project. To determine the role birth timing plays in GrC wiring and function, we developed genetic strategies to access early- and late-born GrCs. We initiated retrograde monosynaptic rabies virus tracing from control (birth timing unrestricted), early-born, and late-born GrCs, revealing the different patterns of mossy fiber input to GrCs in vermis lobule 6 and simplex, as well as to early- and late-born GrCs of vermis lobule 6: sensory and motor nuclei provide more input to early-born GrCs, while basal pontine and cerebellar nuclei provide more input to late-born GrCs. In vivo multidepth two-photon Ca
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