Evidence map›Paper›PMID 34088777›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Silvio R Meier, Dag Sehlin, Sahar Roshanbin, Victoria Lim Falk, Takashi Saito, Takaomi C Saido, Ulf Neumann, Johanna Rokka, Jonas Eriksson, Stina Syvänen

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. PET imaging of TREM2 in amyloid-beta induced neuroinflammation.European journal of nuclear medicine and molecular imaging · 2025
    Article
  4. Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Nuclear Imaging of Bispecific Antibodies on the Rise.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Article
  20. A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Silvio R MeierDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Dag SehlinDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Sahar RoshanbinDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Victoria Lim FalkDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Takashi SaitoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Japan.
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Japan.
Ulf NeumannNeuroscience Research, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Johanna RokkaDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Jonas ErikssonDepartment of Medicinal Chemistry, Uppsala Biomedical Center, Uppsala University, Uppsala, Sweden; and.
Stina SyvänenDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden; stina.syvanen@pubcare.uu.se.
Uppsala University · SERIKEN Center for Brain Science · JPNovartis Institutes for BioMedical Research

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PET imaging of amyloid-β (Aβ) has become an important component of Alzheimer disease diagnosis.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsAnimalsAntibodiesBrainDisease Models, AnimalIodine RadioisotopesMiceMice, TransgenicPlaque, AmyloidPositron-Emission TomographyAmyloid beta-PeptidesAniline CompoundsAntibodiesIodine-124Iodine Radioisotopes11C-PiBAlzheimer diseaseamyloid-βantibody-based PETBACE-1 inhibition

Identifiers

PMID34088777
PMCPMC8805773
OpenAlexW3164476032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.