Evidence map›Paper›PMID 34088769›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.

Christopher M Dustin, Aida Habibovic, Milena Hristova, Caspar Schiffers, Carolyn R Morris, Miao-Chong Joy Lin, Robert A Bauer, David E Heppner, Nirav Daphtary, Minara Aliyeva and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Study ofInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Christopher M DustinDepartment of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT.ORCID 0000-0002-8372-3719
Aida HabibovicDepartment of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT.
Milena HristovaDepartment of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT.ORCID 0000-0002-1320-8332
Caspar SchiffersDepartment of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT.ORCID 0000-0003-2391-1168
Carolyn R MorrisDepartment of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT.ORCID 0000-0002-5200-7859
Miao-Chong Joy LinDepartment of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT.ORCID 0000-0003-3395-070X
Robert A BauerDepartment of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT.
David E HeppnerDepartment of Chemistry, University at Buffalo, State University of New York, Buffalo, NY; and.ORCID 0000-0002-0722-5160
Nirav DaphtaryDepartment of Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT.ORCID 0000-0001-8794-5733
Minara AliyevaDepartment of Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT.
Albert van der VlietDepartment of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT; albert.van-der-vliet@uvm.edu.ORCID 0000-0003-0923-0016
University of Vermont · USUniversity at Buffalo, State University of New York · US

Funding

Dual Oxidase in Airway Epithelial Repair and RemodelingR01HL085646 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2008 to 2020
$4.7M
DUOX1 and Mitochondria in Obese AsthmaR01HL138708 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2017 to 2020
$2.1M
DUOX1 Silencing in Age-Related COPDR21AG055325 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2017 to 2018
$429k
Redox Regulation of Src Kinase in Allergic Airway InflammationF31HL142221 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DUSTIN, CHRISTOPHER MICHAEL · 2018 to 2019
$62k
NHLBI NIH HHS F31 HL142221NHLBI NIH HHS R01 HL085646NHLBI NIH HHS R01 HL138708NIA NIH HHS R21 AG055325
6 · The paper itself

Abstract

The respiratory epithelium forms the first line of defense against inhaled pathogens and acts as an important source of innate cytokine responses to environmental insults. One critical mediator of these responses is the IL-1 family cytokine IL-33, which is rapidly secreted upon acute epithelial injury as an alarmin and induces type 2 immune responses. Our recent work highlighted the importance of the NADPH oxidase dual oxidase 1 (DUOX1) in acute airway epithelial IL-33 secretion by various airborne allergens associated with H

Indexed as

Acute DiseaseAllergensAnimalsCells, CulturedDual OxidasesInterleukin-1 Receptor-Like 1 ProteinInterleukin-33MiceMice, Inbred C57BLMice, KnockoutRespiratory MucosaSignal Transductionsrc-Family KinasesAllergensDual OxidasesDuox1 protein, mouseIl1rl1 protein, mouseIl33 protein, mouseInterleukin-1 Receptor-Like 1 ProteinInterleukin-33src-Family Kinases

Identifiers

PMID34088769
PMCPMC8642476
OpenAlexW3165217825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.