Evidence map›Paper›PMID 34088745›Full record

ArticleScience immunology2021

Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of

Antonia E Gallman, Finn D Wolfreys, David N Nguyen, Moriah Sandy, Ying Xu, Jinping An, Zhongmei Li, Alexander Marson, Erick Lu, Jason G Cyster

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. ABCC1 protects skin dendritic cells from FITC-induced toxicity by efflux and extracellular glutathione buffering.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  10. Cytokines reprogram airway sensory neurons in asthma.bioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Antonia E GallmanHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-9107-8281
Finn D WolfreysHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA. jason.cyster@ucsf.edu finn.wolfreys@ucsf.edu.ORCID 0000-0003-1057-633X
David N NguyenJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0001-6808-2717
Moriah SandyHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-9914-624X
Ying XuHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Jinping AnHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Zhongmei LiJ. David Gladstone Institutes, San Francisco, CA 94158, USA.
Alexander MarsonJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-2734-5776
Erick LuHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-8175-5146
Jason G CysterHoward Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA. jason.cyster@ucsf.edu finn.wolfreys@ucsf.edu.ORCID 0000-0002-4735-9745
Howard Hughes Medical Institute · USGladstone Institutes · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Chemokines and Lymphoid Tissue Organization and FunctionR01AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1999 to 2023
$7.6M
BIOLOGY OF INFECTIOUS DISEASES TRAINING PROGRAMT32AI007641 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2000 to 2026
$6.9M
CRISPR Editing of Primary Human Cells to Model and Correct Primary Immunodeficiency MutationsK08AI153767 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NGUYEN, DAVID-HUY NHU · 2020 to 2024
$994k
Dissecting the role of geranylgeranyl glutathione in the germinal center responseF30AI150061 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GALLMAN, ANTONIA · 2020 to 2022
$121k
Howard Hughes Medical InstituteNIAID NIH HHS F30 AI150061NIAID NIH HHS K08 AI153767NIAID NIH HHS L40 AI140341NIAID NIH HHS R01 AI045073NIAID NIH HHS T32 AI007334NIGMS NIH HHS T32 GM007618
6 · The paper itself

Abstract

P2RY8 promotes the confinement and growth regulation of germinal center (GC) B cells, and loss of human P2RY8 is associated with B cell lymphomagenesis. The metabolite

Indexed as

ATP-Binding Cassette, Sub-Family C Proteinsgamma-GlutamyltransferaseGlutathioneLymphocytesReceptors, Purinergic P2YAnimalsFemaleGene Knockdown TechniquesGene Knockout TechniquesHEK293 CellsHumansLymphocyte ActivationMaleMiceMice, KnockoutATP-Binding Cassette, Sub-Family C Proteinsgamma-GlutamyltransferaseGGT5 protein, humanGgt5 protein, mouseGlutathionemultidrug resistance-associated protein 1P2RY8 protein, humanReceptors, Purinergic P2YS-geranylgeranyl-L-glutathione

Identifiers

PMID34088745
PMCPMC8458272
OpenAlexW3164081680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.