ArticleeNeuro
Short-Term Effects of Vagus Nerve Stimulation on Learning and Evoked Activity in Auditory Cortex.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Vagal nerve stimulation induces vascular oscillations and enhances long-term learning.iScience · 2026Article
- Application of kilohertz-frequency block to mitigate off-target motor effects of vagus nerve stimulation in swine.Nature communications · 2025Article
- How disease threat affects the purchase intention of ultra-processed foods among high-pressure workers.Frontiers in nutrition · 2025Article
- Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning.Nature neuroscience · 2024Article
- Vagus nerve stimulation during training fails to improve learning in healthy rats.Scientific reports · 2024Article
- Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing.Frontiers in neuroscience · 2023Article
- Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation underFrontiers in neuroscience · 2023Article
- Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement.Neuron · 2022Article
- Rapid Effects of Vagus Nerve Stimulation on Sensory Processing Through Activation of Neuromodulatory Systems.Frontiers in neuroscience · 2022Review
- Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve.Nature communications · 2021Article
- A narrative review on invasive brain stimulation for treatment-resistant depression.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chronic vagus nerve stimulation (VNS) has been shown to facilitate learning, but effects of acute VNS on neural coding and behavior remain less well understood. Ferrets implanted with cuff electrodes on the vagus nerve were trained by classical conditioning on an auditory tone frequency-reward association. One tone was associated with reward while another tone was not. Tone frequencies and reward associations were changed every 2 d, requiring learning of a new relationship. When tones were paired with VNS, animals consistently learned the new association within 2 d. When VNS occurred randomly between trials, learning within 2 d was unreliable. In passively listening animals, neural activity in primary auditory cortex (A1) and pupil size were recorded before and after acute VNS-tone pairing. After pairing with a neuron's best-frequency (BF) tone, responses by a subpopulation of neurons were reduced. VNS paired with an off-BF tone or during intertrial intervals had no effect. The BF-specific reduction in neural responses after VNS remained, even after regressing out changes explained by pupil-indexed arousal. VNS induced brief dilation in the pupil, and the size of this change predicted the magnitude of persistent changes in the neural response. This interaction suggests that fluctuations in neuromodulation associated with arousal gate the long-term VNS effects on neural activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.