Evidence map›Paper›PMID 34088712›Full record

ArticleDiabetes2021

Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2.

Callie A S Corsa, Carolyn M Walsh, Devika P Bagchi, Maria C Foss Freitas, Ziru Li, Julie Hardij, Katrina Granger, Hiroyuki Mori, Rebecca L Schill, Kenneth T Lewis and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Multifaceted Roles of Bone Marrow Adipocytes in Bone and Hematopoietic Homeostasis.The Journal of clinical endocrinology and metabolism · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Emerging roles of circular RNAs in osteoporosis.Journal of cellular and molecular medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Callie A S CorsaDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Carolyn M WalshDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Devika P BagchiDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Maria C Foss FreitasDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Ziru LiDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Julie HardijDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Katrina GrangerDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Hiroyuki MoriDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Rebecca L SchillDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Kenneth T LewisDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Jessica N MaungDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Ruth D AzariaDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI.
Amy E RothbergDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Elif A OralDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Ormond A MacDougaldDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI macdouga@umich.edu.ORCID 0000-0001-6907-7960
University of Michigan · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3M
Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
TRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9M
Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
Postdoc Stipend Supplement: Developmental Origins of Metabolic Disorders T32T32DK071212 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON, Kanakadurga Singer · 2005 to 2026
$5.4M
Multidisciplinary Training Program in Basic Diabetes ResearchT32DK101357 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETER ARVAN, Ormond A MacDougald · 2014 to 2026
$4.1M
Mechanisms of adipocyte loss in laminopathy-induced lipodystrophy in mice and humansR01DK125513 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ormond A MacDougald, Elif Arioglu Oral · 2020 to 2026
$3.0M
Mechanisms by which adipocytes adapt to cool environmental temperaturesR01DK121759 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MACDOUGALD, ORMOND A · 2020 to 2024
$2.0M
Mechanisms by Which Bone Marrow Adipose Tissue Expands During Calorie RestrictionF32DK123887 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHILL, REBECCA L. · 2019 to 2021
$161k
NIAMS NIH HHS P30 AR069620NICHD NIH HHS T32 HD007505NIDDK NIH HHS F32 DK122654NIDDK NIH HHS F32 DK123887NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK121759NIDDK NIH HHS R01 DK125513NIDDK NIH HHS R24 DK092759NIDDK NIH HHS T32 DK071212NIDDK NIH HHS T32 DK101357NIDDK NIH HHS U2C DK110768NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

Mechanisms by which autosomal recessive mutations in

Indexed as

AdipocytesAdipogenesisAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsBone DensityDisease Models, AnimalLamin Type ALipodystrophy, Familial PartialMiceMice, KnockoutLamin Type A

Identifiers

PMID34088712
PMCPMC8576431
OpenAlexW3165186804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.